Validation of Fourier decomposition MRI with dynamic contrast-enhanced MRI using visual and automated scoring of pulmonary perfusion in young cystic fibrosis patients
Validation of Fourier decomposition MRI with dynamic contrast-enhanced MRI using visual and automated scoring of pulmonary perfusion in young cystic fibrosis patients
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DOI：
10.1016/j.ejrad.2013.08.018
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发表时间：
2013-12-01
影响因子：
3.3
通讯作者：
Eichinger, Monika
中科院分区：
文献类型：
--
作者：
Bauman, Grzegorz;Puderbach, Michael;Eichinger, Monika
目的：探讨傅立叶分解(FD)磁共振成像在囊性纤维化(CF)患者动态增强(DCE)成像中的应用价值。材料与方法：对34例囊性纤维化患者(年龄0.16~30岁，中位年龄4.08岁)在1.5T磁共振成像仪上进行检查。对于FD MR成像，使用非触发的二维平衡稳态自由进动序列采集多组肺部图像。对时间分辨数据集进行呼吸位移校正和心率傅立叶分析后，得到灌注加权图像。用三维梯度回波序列采集DCE数据集。使用基于场的评分系统(0-12)，由两个读取器(R1、R2)独立地对FD和DCE图像的血流灌注缺陷进行视觉评估。使用软件使用自动阈值对分割的肺图像进行灌注损伤评估(R3)。结果：FD和DCE在视觉和自动评分方面存在良好或可接受的符合度：R1：ULA，LLA：2.72，2.5；R2：ULA，LLA：+2.5；R3：ULA：1.5，LLA：2。视觉评分和自动评分的符合率很高(FD：70-80%，DCE：73-84%)。结论：FD MR成像提供了与DCE MR成像相同的诊断信息。使用FD和DCE MR成像对局部灌注缺陷的自动评估可与视觉评分相媲美，但允许基于百分比的分析。(C)2013爱思唯尔爱尔兰有限公司。保留所有权利。
Purpose: To validate Fourier decomposition (FD) magnetic resonance (MR) imaging in cystic fibrosis (CF) patients with dynamic contrast-enhanced (DCE) MR imaging.Materials and methods: Thirty-four CF patients (median age 4.08 years; range 0.16-30) were examined on a 1.5-T MR imager. For FD MR imaging, sets of lung images were acquired using an untriggered twodimensional balanced steady-state free precession sequence. Perfusion-weighted images were obtained after correction of the breathing displacement and Fourier analysis of the cardiac frequency from the time-resolved data sets. DCE data sets were acquired with a three-dimensional gradient echo sequence. The FD and DCE images were visually assessed for perfusion defects by two readers independently (R1, R2) using a field based scoring system (0-12). Software was used for perfusion impairment evaluation (R3) of segmented lung images using an automated threshold. Both imaging and evaluation methods were compared for agreement and tested for concordance between FD and DCE imaging.Results: Good or acceptable intra-reader agreement was found between FD and DCE for visual and automated scoring: R1 upper and lower limits of agreement (ULA, LLA): 2.72, 2.5; R2: ULA, LLA: +2.5; R3: ULA: 1.5, LLA: 2. A high concordance was found between visual and automated scoring (FD: 70-80%, DCE: 73-84%).Conclusions: FD MR imaging provides equivalent diagnostic information to DCE MR imaging in CF patients. Automated assessment of regional perfusion defects using FD and DCE MR imaging is comparable to visual scoring but allows for percentage-based analysis. (C) 2013 Elsevier Ireland Ltd. All rights reserved.