Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans
Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans
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DOI：
10.1007/s00125-012-2466-8
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发表时间：
2012-05-01
期刊：
影响因子：
8.2
通讯作者：
Menge, B. A.
中科院分区：
文献类型：
--
作者：
Meier, J. J.;Breuer, T. G. K.;Menge, B. A.
目的/假设糖尿病经常发生在胰腺疾病患者中。我们的目的是确定低阈值的β细胞面积糖尿病的表现，以及胰岛素敏感性对葡萄糖稳态的影响，在patients with pancreatic diabetes.Methods 82例接受胰腺手术的患者进行术前口服葡萄糖挑战。结果高、中β细胞面积患者的糖化血红蛋白（1c）和血糖水平相似，而低β细胞面积患者的糖化血红蛋白（1c）和血糖水平显著高于低β细胞面积患者（P
Aims/hypothesis Diabetes frequently develops in patients with pancreatic disorders. We aimed to determine the lower threshold of beta cell area for diabetes manifestation as well as the impact of insulin sensitivity on glucose homoeostasis in patients with pancreatic diabetes.Methods Eighty-two patients undergoing pancreatic surgery underwent pre-operative oral glucose challenge. Fractional pancreatic beta cell area was determined, and indices of insulin sensitivity and beta cell function were calculated.Results HbA(1c) and glucose levels were similar in patients with high and intermediate beta cell area, but were significantly higher in those with the lowest beta cell area (p