Evaluation of a novel biomaterial in the suprachoroidal space of the rabbit eye.
Evaluation of a novel biomaterial in the suprachoroidal space of the rabbit eye.
复制标题
兔眼脉络膜上腔新型生物材料的评估。
DOI：
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复制
发表时间：
2002
影响因子：
4.4
通讯作者：
F. Behar
中科院分区：
文献类型：
--
作者：
S. Einmahl;M. Savoldelli;F. D'hermies;C. Tabatabay;R. Gurny;F. Behar
目的
用于治疗眼后段疾病（例如脉络膜新生血管形成及其并发症）的药物递送受到眼内渗透性差和药物从眼内快速消除的阻碍。本研究的目的是探讨脉络膜上注射聚原酸酯（POE）的可行性和耐受性，POE是一种生物可蚀性和生物相容性聚合物，作为一种生物材料，可能用于开发持续给药系统。
方法
巩膜隧道化后，将基于POE的不同制剂注射（100微升）到有色兔的脉络膜上腔中，并与1%透明质酸钠进行比较。随访包括眼底观察，回声描记术，荧光素血管造影术和组织学分析超过3周。
结果
注射后，POE在后极的脉络膜上腔中扩散。耐受性良好，从注射部位逐渐消失，无后遗症。未发生出血或视网膜脱离。超声图像显示，材料存在于脉络膜上腔3周。血管造影显示注射部位有轻微的色素不规则，但没有视网膜水肿或坏死。组织学显示POE在脉络膜中耐受良好。
结论
POE脉络膜上腔注射，一个简单的，可控的，可重复的程序，在兔眼耐受性良好。POE似乎是一种有前途的生物材料，将药物局部递送到脉络膜和视网膜。
PURPOSE
Drug delivery to treat diseases of the posterior segment of the eye, such as choroidal neovascularization and its complications, is hampered by poor intraocular penetration and rapid elimination of the drug from the eye. The purpose of this study was to investigate the feasibility and tolerance of suprachoroidal injections of poly(ortho ester) (POE), a bioerodible and biocompatible polymer, as a biomaterial potentially useful for development of sustained drug delivery systems.
METHODS
After tunnelization of the sclera, different formulations based on POE were injected (100 microL) into the suprachoroidal space of pigmented rabbits and compared with 1% sodium hyaluronate. Follow-up consisted of fundus observations, echography, fluorescein angiography, and histologic analysis over 3 weeks.
RESULTS
After injection, POE spread in the suprachoroidal space at the posterior pole. It was well tolerated and progressively disappeared from the site of injection without sequelae. No bleeding or retinal detachment occurred. Echographic pictures showed that the material was present in the suprachoroidal space for 3 weeks. Angiography revealed minor pigment irregularities at the site of injection, but no retinal edema or necrosis. Histology showed that POE was well tolerated in the choroid.
CONCLUSIONS
POE suprachoroidal injections, an easy, controllable, and reproducible procedure, were well tolerated in the rabbit eye. POE appears to be a promising biomaterial to deliver drugs focally to the choroid and the retina.
血管抑制类固醇和β-环糊精十四硫酸酯对大鼠角膜新生血管的影响。
影响因子：
3.4
作者：
Proia,AD;Hirakata,A;McInnes,JS;Scroggs,MW;Parikh,I
通讯作者：
Parikh,I