Brain alpha-adrenoceptors in depressed suicides
Brain alpha-adrenoceptors in depressed suicides
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DOI：
10.1016/s0006-8993(97)00138-8
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发表时间：
1997-05-16
期刊：
影响因子：
2.9
通讯作者：
Horton, RW
中科院分区：
文献类型：
--
作者：
DePaermentier, F;Mauger, JM;Horton, RW
通过放射性配体与脑组织匀浆的结合来测量α（1）-肾上腺素能受体和α（2）-肾上腺素能受体，这些脑组织是从自杀者和年龄和性别匹配的对照组中获得的，这些自杀者具有抑郁症的回顾性诊断。自杀者被细分为那些至少三个月没有服用抗抑郁药物的人，以及那些明确记录抗抑郁药物处方的人。α（1）-肾上腺素能受体（或α（1A）+ α（1D）-肾上腺素能受体）的数量在无抗抑郁药或抗抑郁药治疗的自杀者和对照组之间没有显著差异。在不使用抗抑郁药的自杀者中，颞叶皮层的α 2-肾上腺素能受体数量显著增加（Ba 21/22）。在该脑区，α（2A）-肾上腺素受体与对照组无显著差异，表明其他α（2）-肾上腺素受体亚型也参与其中。与对照组相比，在抗抑郁药治疗的自杀者中，在枕叶皮质和海马中发现了显著较低数量的α（2）-肾上腺素受体（以及尾状核和杏仁核中的α（2A）-肾上腺素受体）。(C)1997年Elsevier Science B.V.
alpha(1)-Adrenoceptors and alpha(2)-adrenoceptors were measured by radioligand binding to homogenates of brain samples obtained at post-mortem from suicides with a retrospective diagnosis of depression, and age and gender-matched controls. Suicides were subdivided into those who had been free of antidepressant drugs for at least three months, and those in whom prescription of antidepressant drugs was clearly documented. The number of alpha(1)-adrenoceptors (or alpha(1A) + alpha(1D)-adrenoceptors) did not differ significantly between antidepresant-free or antidepressant-treated suicides and controls. In antidepressant-free suicides, the number of alpha(2)-adrenoceptors was significantly higher in temporal cortex (Ba 21/22). alpha(2A)-Adrenoceptors did not differ significantly from controls in this brain region, suggesting the involvement of other alpha(2)-adrenoceptor subtypes. In antidepressant-treated suicides, significantly lower numbers of alpha(2)-adrenoceptors were found in occipital cortex and hippocampus (and for alpha(2A)-adrenoceptors in caudate and amygdala) compared to controls. (C) 1997 Elsevier Science B.V.