Anti-inflammatory activity of Chinese medicinal vine plants
Anti-inflammatory activity of Chinese medicinal vine plants
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DOI：
10.1016/s0378-8741(02)00339-2
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发表时间：
2003-03-01
影响因子：
5.4
通讯作者：
Leach, DN
中科院分区：
文献类型：
--
作者：
Li, RW;Lin, GD;Leach, DN
从传统中药中用于治疗炎症条件的九种藤本植物的乙醇提取物的抗炎活性针对与炎症相关的一组关键酶进行了评价。这些酶包括环氧合酶-1（考克斯-1）、环氧合酶-2（考克斯-2）、磷脂酶A（2）（PLA（2））、5-脂氧合酶（5-LO）和12-脂氧合酶（12-LO）。所研究的藤本植物有：鸡血藤的茎，络石藤的茎，雷公藤（Tripterygium wilfordii Hook.）f.根据权利要求1，青风藤的茎、海风藤的茎、何首乌的茎，从青牛胆（Tinospora sagittata Gagnep.）青牛胆（Tinospora sinensis（Lour.））梅里尔和威灵仙的茎。所有的植物提取物都显示出对至少一种酶的抑制活性，其抑制活性取决于浓度的不同百分比。S.发现亚直肌对除考克斯-2以外的所有酶都有活性。在考克斯-1、PLA（2）、5-LO和12-LO试验中，其IC 50值分别为158、54、31和35 μ g/ml。T.茉莉花提取物对考克斯-1（IC 50 35 μ g/ml）和PLA（2）（IC 50 33 μ g/ml）均表现出较强的抑制活性。其中，木霉提取物对考克斯-1、考克斯-2和5-LO的抑制作用最强。Wilfordii的IC 50值分别为27、125和22 μ g/ml。这项研究的结果可能部分解释了这些藤本植物在传统中药中用于治疗炎症的原因。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Anti-inflammatory activities of ethanol extracts from nine vine plants used in traditional Chinese medicine to treat inflammatory conditions were evaluated against a panel of key enzymes relating to inflammation. The enzymes included cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), phospholipase A(2) (PLA(2)), 5-lipoxygenase (5-LO) and 12-lipoxygenase (12-LO). The vine plants studied were: the stem of Spatholobus suberectus Dunn, the stem of Trachelospermum jasminoides Lem., the root from Tripterygium wilfordii Hook. f., the stem of Sinomenium acutum Rehder and Wilson, the stem of Piper kadsura (Choisy) Ohwi, the stem of Polygonum multiflorum Thunb., the root and stem from Tinospora sagittata Gagnep., the root of Tinospora sinensis (Lour.) Merrill, and the stem of Clematis chinensis Osbeck. All of the plant extracts showed inhibitory activities against at least one of the enzymes in various percentages depending upon the concentrations. The extract from S. suberectus was found to be active against all enzymes except COX-2. Its IC50 values were 158, 54, 31 and 35 mug/ml in COX-1, PLA(2), 5-LO and 12-LO assays, respectively. T. jasminoides showed potent inhibitory activities against both COX-1 (IC50 35 mug/ml) and PLA(2) (IC50 33 mug/ml). The most potent COX-1, COX-2 and 5-LO inhibition was observed in the extract of T. wilfordii with the IC50 values of 27, 125 and 22 mug/ml, respectively. The findings of this study may partly explain the use of these vine plants in traditional Chinese medicine for the treatment of inflammatory conditions. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.