Psychedelic use is associated with reduced daily opioid use among people who use illicit drugs in a Canadian setting.
Psychedelic use is associated with reduced daily opioid use among people who use illicit drugs in a Canadian setting.
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DOI：
10.1016/j.drugpo.2021.103518
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
DeBeck K
中科院分区：
文献类型：
--
作者：
Argento E;Socias ME;Hayashi K;Choi J;Mackay L;Christie D;Milloy MJ;DeBeck K
近年来，对致幻剂用于改善与精神健康障碍有关的结果的治疗和自然用途的研究引起了越来越多的兴趣。虽然迷幻药的对照临床试验表明了治疗物质使用障碍的益处，但在自然主义迷幻药使用的背景下，这一领域尚未得到很好的研究。本研究旨在调查最近自然主义迷幻剂使用与随后的每日非法阿片类药物使用之间的可能关系。数据（2006-2018年）来自加拿大温哥华社区招募的三个统一前瞻性队列。我们使用多变量广义线性混合效应模型（GLMM）来估计迷幻剂使用和随后的每日非法阿片类药物使用之间的独立关联。在基线的3813名PWUD中，1093名（29%）报告每天使用非法阿片类药物，229名（6%）报告在过去六个月内使用迷幻剂。在对一系列潜在混杂因素进行调整后的研究随访中，迷幻剂的使用仍然与随后每日阿片类药物使用的几率显著降低独立相关（调整后的比值比：0.45; 95%置信区间：0.29至0.70）。虽然需要在其他环境中进行确认，但这些发现与越来越多的证据相一致，即迷幻剂的使用可能与随后物质使用（包括非法阿片类药物使用）的可检测减少有关。
Research into the therapeutic and naturalistic uses of psychedelics for improving outcomes related to mental health disorders has generated increasing interest in recent years. While controlled clinical trials of psychedelics have signaled benefits for treating substance use disorders, this area has not been well studied in the context of naturalistic psychedelic use. This study sought to investigate the possible relationship between recent naturalistic psychedelic use and subsequent daily illicit opioid use among people who use drugs (PWUD). Data (2006–2018) were drawn from three harmonized prospective cohorts of community-recruited PWUD in Vancouver, Canada. We used multivariable generalized linear mixed-effects modeling (GLMM) to estimate the independent association between psychedelic use and subsequent daily illicit opioid use. Among 3813 PWUD at baseline, 1093 (29%) reported daily use of illicit opioids and 229 (6%) reported psychedelic use in the past six months. Over study follow-up after adjusting for a range of potential confounders, psychedelic use remained independently associated with a significantly reduced odds of subsequent daily opioid use (Adjusted Odds Ratio: 0.45; 95% Confidence Interval: 0.29 to 0.70). While confirmation in other settings is required, these findings align with growing evidence that psychedelic use may be associated with detectable reductions in subsequent substance use including illicit opioid use.
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DOI：
10.1111/add.15054
发表时间：
2020-11
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Cleveland LM;McGlothen-Bell K;Scott LA;Recto P
通讯作者：
Recto P
影响因子：
4.4
作者：
Argento, Elena;Chettiar, Jill;Shannon, Kate
通讯作者：
Shannon, Kate
影响因子：
4.5
作者：
George, Jamilah R.;Michaels, Timothy I.;Williams, Monnica T.
通讯作者：
Williams, Monnica T.
影响因子：
4.1
作者：
Agin-Liebes, Gabrielle, I;Malone, Tara;Ross, Stephen
通讯作者：
Ross, Stephen
影响因子：
25.8
作者：
Davis AK;Barrett FS;May DG;Cosimano MP;Sepeda ND;Johnson MW;Finan PH;Griffiths RR
通讯作者：
Griffiths RR