Artificial Collagen Gels via Self-Assembly of De Novo Designed Peptides
Artificial Collagen Gels via Self-Assembly of De Novo Designed Peptides
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DOI：
10.1002/bip.21100
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发表时间：
2008-01-01
期刊：
影响因子：
2.9
通讯作者：
Koide, Takaki
中科院分区：
文献类型：
--
作者：
Yamazaki, Chisato M.;Asada, Shinichi;Koide, Takaki
开发人造胶原蛋白来替代动物来源的胶原蛋白是形成更安全和功能更好的生物材料的一个挑战。我们在这里报道了通过化学合成的多肽的自组装来开发类胶原凝胶的方法。这些多肽是胶原蛋白Gly-X-Y三联体的二硫键连接的三聚体，具有自我互补的形状。当多肽溶液冷却时，多肽超分子的水凝胶通过自发的分子间三螺旋形成。热凝胶-溶胶的转变似乎是可逆的，转变温度可以通过多肽的设计来调节。我们用于形成人造胶原样凝胶的系统将为新型生物材料提供可能性。(C)2008 Wiley期刊，Inc.生物聚合物(Pept Sci)90：816-823,2008。
Development of artificial collagens to replace the animal-derived collagens presents a challenge in the formation of safer and functional biomaterials. We report here the development of collagen-like gels by means of the self-assembly of chemically synthesized peptides. The peptides are disulfide-linked trimers of collagenous Gly-X-Y triplet repeats with self-complementary shapes. Upon cooling the peptide solutions, hydrogels of peptide supramolecules are formed by spontaneous intermolecular triple helix formation. The thermal gel-sol transition appeared to be reversible and the transition temperatures were found to be tunable by the design of the peptides. Our systems for the formation of artificial collagen-like gels will offer possibilities for novel types of biomaterials. (C) 2008 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 90: 816-823, 2008.