Metabolic tumor volume predicts for recurrence and death in head-and-neck cancer.
Metabolic tumor volume predicts for recurrence and death in head-and-neck cancer.
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DOI：
10.1016/j.ijrobp.2008.10.060
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发表时间：
2009-08-01
影响因子：
7
通讯作者：
Le, Quynh-Thu
中科院分区：
文献类型：
--
作者：
La, Trang H.;Filion, Edith J.;Turnbull, Brit B.;Chu, Jackie N.;Lee, Percy;Nguyen, Khoa;Maxim, Peter;Quon, Andy;Graves, Edward E.;Loo, Billy W., Jr.;Le, Quynh-Thu
关键词：
目的：评价18F-脱氧葡萄糖正电子发射断层扫描(FDG-PET)测量的代谢性肿瘤体积和其他临床因素在单一机构治疗的局部晚期头颈癌患者中的预后价值。从2003年3月至2007年8月，85名患者接受了PET/CT引导下的HNC放化疗。代谢活跃的肿瘤区域在预处理的PET扫描上使用定制软件半自动描绘出来。我们评估FDG-PET最大标准摄取值(SUV)和总代谢性肿瘤体积(MTV)与无病生存期(DFS)和总生存期(OS)的关系。存活患者的平均随访时间为20.4个月。估计2年局部区域控制率、DFS和OS分别为88.0%、69.5%和78.4%。16例复发患者首次失败的中位时间为9.8个月。即使在控制了卡诺夫斯基表现状态(Kps)(1.8倍，p=0.001)和死亡(2.1倍，p<；0.001)之后，MTV增加17.4mL(第75个百分位数和第25个百分位数之间的差异)与首次事件(复发或死亡)的风险(1.9倍，p<；0.001)显著相关。我们没有发现最大SUV、分期或其他临床因素与DFS或OS之间的显著关系。新陈代谢肿瘤体积是HNC疾病复发和死亡的不良预后因素。在控制了KPS后，MTV仍然具有重要意义，KPS是在该队列中发现的唯一另一个显著的不良预后因素。MTV是肿瘤负担的直接测量，是未来研究中风险分层和指导治疗的潜在有价值的工具。
To evaluate the prognostic value of metabolic tumor volume measured on 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging and other clinical factors in patients treated for locally advanced head and neck cancer at a single institution. From March 2003 to August 2007, 85 patients received PET/CT-guided chemoradiotherapy for HNC. Metabolically active tumor regions were delineated on pretreatment PET scans semi-automatically using custom software. We evaluated the relationship of FDG-PET maximum standardized uptake value (SUV) and total metabolic tumor volume (MTV) with disease-free survival (DFS) and overall survival (OS). Mean follow-up for surviving patients was 20.4 months. The estimated 2-year locoregional control, DFS, and OS for the group were 88.0%, 69.5% and 78.4%, respectively. The median time to first failure was 9.8 months among the 16 patients with relapse. An increase in MTV of 17.4 mL (difference between the 75th and 25th percentiles) was significantly associated with an increased hazard of first event (recurrence or death) (1.9-fold, p<0.001), even after controlling for Karnofsky performance status (KPS) (1.8-fold, p=0.001), and of death (2.1-fold, p<0.001). We did not find a significant relationship of maximum SUV, stage, or other clinical factors with DFS or OS. Metabolic tumor volume is an adverse prognostic factor for disease recurrence and death in HNC. MTV retained significance after controlling for KPS, the only other significant adverse prognostic factor found in this cohort. MTV is a direct measure of tumor burden and is a potentially valuable tool for risk stratification and guiding treatment in future studies.
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DOI：
10.1016/j.ijrobp.2007.04.036
发表时间：
2007-10-01
影响因子：
7
作者：
Lee, Percy;Weerasuriya, Dilam K.;Loo, Billy W.
通讯作者：
Loo, Billy W.
影响因子：
45.3
作者：
Wong, RJ;Lin, DT;Kraus, DH
通讯作者：
Kraus, DH
影响因子：
158.5
作者：
Bonner, JA;Harari, PM;Ang, KK
通讯作者：
Ang, KK
DOI：
10.1002/hed.20734
发表时间：
2008-04-01
影响因子：
2.9
作者：
Johansen, Jorgen;Buus, Simon;Overgaard, Jens
通讯作者：
Overgaard, Jens
影响因子：
3.8
作者：
Roh, J.-L.;Pae, K. H.;Kim, S. Y.
通讯作者：
Kim, S. Y.