Hooked! Modeling human disease in zebrafish
Hooked! Modeling human disease in zebrafish
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DOI：
10.1172/jci60434
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发表时间：
2012-07-01
影响因子：
15.9
通讯作者：
Zon, Leonard I.
中科院分区：
文献类型：
--
作者：
Santoriello, Cristina;Zon, Leonard I.
斑马鱼被广泛用作研究发育过程的模型系统，但在过去十年中，它们也成为模拟人类疾病的有价值的系统。斑马鱼器官的发育和功能与人类器官惊人地相似，创造突变或转基因鱼的便捷性促进了疾病模型的产生。在这里，我们强调使用斑马鱼来定义疾病途径和发现新的治疗方法。
Zebrafish have been widely used as a model system for studying developmental processes, but in the last decade, they have also emerged as a valuable system for modeling human disease. The development and function of zebrafish organs are strikingly similar to those of humans, and the ease of creating mutant or transgenic fish has facilitated the generation of disease models. Here, we highlight the use of zebrafish for defining disease pathways and for discovering new therapies.