From transcription to transport: emerging roles for nuclear myosin I
From transcription to transport: emerging roles for nuclear myosin I
复制标题
DOI：
10.1139/o06-069
复制
发表时间：
2006-08-01
期刊：
影响因子：
--
通讯作者：
de Lanerolle, Primal
中科院分区：
文献类型：
--
作者：
Hofmann, Wilma A.;Johnson, Terezina;de Lanerolle, Primal
肌球蛋白是肌动蛋白激活的ATPase的超家族，在细胞质中与肌动蛋白一起作为分子马达工作。多年来，肌动蛋白在细胞核中的存在已为人所知。肌球蛋白的核异构体--核肌球蛋白I(NMI)的展示激发了人们对Acto-NMI复合体可能的核内运动功能的极大兴趣。NMI被证明参与了RNA聚合酶I和II的转录。在这两种情况下，NMI都与各自的聚合酶相互作用，并在转录的基本过程中起关键作用。最近一项关于核内远距离染色体运动的研究表明，NMI在染色体区域的易位中也起到了作用。此外，这种运动是基于Acto-NMI复合体促进的积极和定向的过程，首次确立了由肌动蛋白和肌球蛋白组成的核内运动复合体的功能作用。
Myosins are a superfamily of actin-activated ATPases that, in the cytoplasm, work together with actin as molecular motors. The presence of actin in the nucleus has been known for many years. The demonstration of a nuclear isoform of a myosin, nuclear myosin I (NMI), stimulated a great deal of interest in possible intranuclear motor functions of an acto-NMI complex. NMI has been shown to be involved in transcription by RNA polymerases I and II. In both cases, NMI interacts with the respective polymerase and is critically involved in the basic process of transcription. A recent study on intranuclear long-range chromosome movement has now demonstrated a role for NMI in the translocation of chromosome regions as well. Moreover, this movement is based on an active and directed process that is facilitated by an acto-NMI complex, establishing for the first time a functional role for a motor complex consisting of actin and a myosin in the nucleus.