Phthalate exposure and children's health.
Phthalate exposure and children's health.
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DOI：
10.1097/mop.0b013e32835e1eb6
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发表时间：
2013-04
影响因子：
3.6
通讯作者：
Hauser R
中科院分区：
文献类型：
--
作者：
Braun JM;Sathyanarayana S;Hauser R
邻苯二甲酸酯是用于个人护理产品、药物和塑料的多功能化学品。我们回顾了流行病学文献，考察了早期邻苯二甲酸酯暴露与儿科健康结局之间的关系。来自亚洲、欧洲和美国的五项研究表明，儿童时期接触邻苯二甲酸二乙基己酯(DEHP)和邻苯二甲酸丁基苄酯(BBZP)可能会增加患过敏性疾病的风险，包括哮喘和湿疹。来自四个不同预期队列的六项研究报告称，妊娠期BBZP、DEHP、邻苯二甲酸二丁酯(DBP)和邻苯二甲酸二乙酯(DEP)暴露与婴儿/幼儿身体发育的变化以及父母报告的外化、内化和自闭症样儿童行为有关。然而，在特定的邻苯二甲酸盐和行为领域存在不一致。两项小型研究报告称，孕期邻苯二甲酸盐暴露较高的男婴的肛门距离较短。几项流行病学研究表明，胎儿和儿童接触一些邻苯二甲酸盐可能会扰乱正常发育，几项研究一直报告称，接触DEHP和BBzP会增加患过敏性疾病的风险。虽然预见性指导目前还不是基于证据的，但提供者可以建议相关患者减少邻苯二甲酸盐的暴露，以保护发育中的胎儿和儿童免受潜在的不利健康后果。
Phthalates are multifunctional chemicals used in personal care products, medications, and plastics. We reviewed the epidemiological literature examining the relationship between early life phthalate exposure and pediatric health outcomes. Five studies from Asia, Europe, and the US suggest that childhood exposure to di-2-ethylhexyl phthalate (DEHP) and butylbenzyl phthalate (BBzP) may increase the risk of allergic diseases including asthma and eczema. Six studies from four different prospective cohorts report that gestational BBzP, DEHP, di-butyl phthalate (DBP), and di-ethyl phthalate (DEP) exposures are associated with alterations in infant/toddler physical development as well as parent-reported externalizing, internalizing, and autistic-like child behavior. However, there are inconsistencies related to the specific phthalates and behavioral domains. Two small studies report shorter anogenital distance among male infants with higher gestational phthalate exposure. Several epidemiological studies suggest fetal and childhood exposure to some phthalates may perturb normal development, with several studies consistently reporting increased risk of allergic diseases with DEHP and BBzP exposure. While anticipatory guidance is not evidence-based at this time, providers can counsel concerned patients to reduce phthalate exposures in order to protect the developing fetus and child from potential adverse health outcomes.