Risk factors for COVID-19 diagnosis, hospitalization, and subsequent all-cause mortality in Sweden: a nationwide study.
Risk factors for COVID-19 diagnosis, hospitalization, and subsequent all-cause mortality in Sweden: a nationwide study.
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瑞典COVID-19诊断、住院和随后全因死亡的风险因素：一项全国性研究
DOI：
10.1007/s10654-021-00732-w
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发表时间：
2021-03
影响因子：
13.6
通讯作者：
Nordström P
中科院分区：
文献类型：
--
作者：
Bergman J;Ballin M;Nordström A;Nordström P
我们进行了一项基于登记的全国性研究，调查34个潜在风险因素对冠状病毒病2019年(新冠肺炎)诊断、住院(有或没有重症监护病房[ICU]入院)以及随后全原因死亡的重要性。研究人群包括截至2020年9月中旬瑞典确诊的所有新冠肺炎病例(68,575例非住院病例，2,494例ICU住院病例，13,589例非ICU住院病例)和434,081例随机抽样的普通人群对照。年龄是住院的最大危险因素，尽管60-69岁以后ICU住院的几率下降，在控制了其他危险因素后，40-49岁以后非ICU住院的几率没有趋势。居住在长期护理机构与非ICU住院有关。男性和至少一种被调查的合并症或处方药的存在与ICU和非ICU住院有关。与ICU和非ICU住院相关的三种并发症是哮喘、高血压和唐氏综合征。癌症病史与新冠肺炎住院无关，但在控制了其他危险因素后，过去一年的癌症与非重症监护病房住院有关。在调整了其他危险因素后，心血管疾病与新冠肺炎的非重症监护室住院的相关性较弱，但与重症监护病房的住院率无关。在住院和非住院的新冠肺炎病例中均观察到超额死亡率。这些结果证实，严重的新冠肺炎与年龄、性别和一般情况下的合并症有关。这项研究提供了新的证据，表明高血压、哮喘、唐氏综合症和长期护理机构的居住与严重的新冠肺炎有关。网上版载有补充材料，可在10.1007/s10654-021-00732-w查阅。
We conducted a nationwide, registry-based study to investigate the importance of 34 potential risk factors for coronavirus disease 2019 (COVID-19) diagnosis, hospitalization (with or without intensive care unit [ICU] admission), and subsequent all-cause mortality. The study population comprised all COVID-19 cases confirmed in Sweden by mid-September 2020 (68,575 non-hospitalized, 2494 ICU hospitalized, and 13,589 non-ICU hospitalized) and 434,081 randomly sampled general-population controls. Older age was the strongest risk factor for hospitalization, although the odds of ICU hospitalization decreased after 60–69 years and, after controlling for other risk factors, the odds of non-ICU hospitalization showed no trend after 40–49 years. Residence in a long-term care facility was associated with non-ICU hospitalization. Male sex and the presence of at least one investigated comorbidity or prescription medication were associated with both ICU and non-ICU hospitalization. Three comorbidities associated with both ICU and non-ICU hospitalization were asthma, hypertension, and Down syndrome. History of cancer was not associated with COVID-19 hospitalization, but cancer in the past year was associated with non-ICU hospitalization, after controlling for other risk factors. Cardiovascular disease was weakly associated with non-ICU hospitalization for COVID-19, but not with ICU hospitalization, after adjustment for other risk factors. Excess mortality was observed in both hospitalized and non-hospitalized COVID-19 cases. These results confirm that severe COVID-19 is related to age, sex, and comorbidity in general. The study provides new evidence that hypertension, asthma, Down syndrome, and residence in a long-term care facility are associated with severe COVID-19. The online version contains supplementary material available at 10.1007/s10654-021-00732-w.
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DOI：
10.1016/s2213-2600(20)30558-0
发表时间：
2021-03
期刊：
The Lancet. Respiratory medicine
影响因子：
--
作者：
Cohen JB;Hanff TC;William P;Sweitzer N;Rosado-Santander NR;Medina C;Rodriguez-Mori JE;Renna N;Chang TI;Corrales-Medina V;Andrade-Villanueva JF;Barbagelata A;Cristodulo-Cortez R;Díaz-Cucho OA;Spaak J;Alfonso CE;Valdivia-Vega R;Villavicencio-Carranza M;Ayala-García RJ;Castro-Callirgos CA;González-Hernández LA;Bernales-Salas EF;Coacalla-Guerra JC;Salinas-Herrera CD;Nicolosi L;Basconcel M;Byrd JB;Sharkoski T;Bendezú-Huasasquiche LE;Chittams J;Edmonston DL;Vasquez CR;Chirinos JA
通讯作者：
Chirinos JA
影响因子：
120.7
作者：
Fosbol, Emil L.;Butt, Jawad H.;Kober, Lars
通讯作者：
Kober, Lars
影响因子：
158.5
作者：
Mancia, Giuseppe;Rea, Federico;Corrao, Giovanni
通讯作者：
Corrao, Giovanni
影响因子：
13.6
作者：
Brooke HL;Talbäck M;Hörnblad J;Johansson LA;Ludvigsson JF;Druid H;Feychting M;Ljung R
通讯作者：
Ljung R
影响因子：
105.7
作者：
Docherty, Annemarie B.;Harrison, Ewen M.;Semple, Malcolm G.
通讯作者：
Semple, Malcolm G.