Biological complexity is under the 'strange attraction' of non-esterified fatty acids
Biological complexity is under the 'strange attraction' of non-esterified fatty acids
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DOI：
10.1016/s0952-3278(97)90500-7
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发表时间：
1997-07-01
影响因子：
3
通讯作者：
Nunez, EA
中科院分区：
文献类型：
--
作者：
Nunez, EA
现在从大量数据中可以清楚地看出，非酯化脂肪酸（NEFA）无需任何代谢修饰即可作为哺乳动物特有的复杂信号网络的第二信使或调节剂。该网络可以做出不同的反应，以使生物体适应各种内源性和外源性环境情况。 NEFA具有广泛的分子结构，因此可以对该信号网络发挥不同的特异性调节作用，例如放大、抑制或信号重定向。我们选择“奇怪的吸引力”一词来描述这些信号调制，与确定性混沌理论中引入的“奇怪的吸引力”概念进行类比。 NEFA 可以调节哺乳动物各个组织层次（分子、细胞、组织、器官等）的功能。
It is now clear from numerous data that non-esterified fatty acids (NEFAs) can act without any metabolic modification as second messengers or modulators of the complex signalling network which is characteristic of mammals. This network can respond differently to adapt the organism to the various endogenous and exogenous environmental situations. NEFAs have a wide range of molecular structures, and thus can exert different specific modulatory actions on this signalling network, such as amplification, inhibition or signal redirection. We have chosen the term 'strange attractions' to describe these signalling modulations by analogy with the 'strange attractions' concept introduced in deterministic chaos theory. NEFAs can modulate the functions of mammals at all levels of organization (molecular, cellular, tissue, organ, etc).