A 2ND-GENERATION LINKAGE MAP OF THE HUMAN GENOME
A 2ND-GENERATION LINKAGE MAP OF THE HUMAN GENOME
复制标题
DOI：
10.1038/359794a0
复制
发表时间：
1992-10-29
期刊：
影响因子：
64.8
通讯作者：
LATHROP, M
中科院分区：
文献类型：
--
作者：
WEISSENBACH, J;GYAPAY, G;LATHROP, M
对来自8个大家族的814个新发现的包含(C-A)n重复短片段的多态基因座进行分离分析，构建了人类基因组的连锁图谱。统计连锁分析将813个标记归入对应于22个常染色体和X染色体的23个连锁群；605个标记的杂合度超过0.7,553个标记的优势比超过1000：1。所跨越的距离大约相当于人类基因组估计长度的90%。
A linkage map of the human genome has been constructed based on the segregation analysis of 814 newly characterized polymorphic loci containing short tracts of (C-A)n repeats in a panel of DNAs from eight large families. Statistical linkage analysis placed 813 of the markers into 23 linkage groups corresponding to the 22 autosomes and the X chromosome; 605 show a heterozygosity above 0.7 and 553 could be ordered with odds ratios above 1,000:1. The distance spanned corresponds to approximately 90% of the estimated length of the human genome.