The control of neural stem cells by morphogenic signals.
The control of neural stem cells by morphogenic signals.
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DOI：
10.1016/s0959-437x(02)00329-5
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发表时间：
2002-08
影响因子：
4
通讯作者：
David M. Panchision;R. McKay
中科院分区：
文献类型：
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作者：
David M. Panchision;R. McKay
神经系统的正常发育需要干细胞的特化、扩增和分化的复杂协调。尽管在这些过程中单个基因的作用方面已经取得了进展，但关于基因功能如何转化为细胞动态组装成组织的问题仍然没有解决。近年来，干细胞生物学已成为传统细胞生物学和发育遗传学之间的桥梁。除了潜在的治疗作用外，干细胞还被用作实验性的“逻辑芯片”，可以整合信息并表现出自组织特性。最近的研究为形态发生信号如何协调主要干细胞决定以调节神经系统的大小，形状和细胞多样性提供了新的见解。
A complex orchestration of stem-cell specification, expansion and differentiation is required for the proper development of the nervous system. Although progress has been made on the role of individual genes in each of these processes, there are still unresolved questions about how gene function translates to the dynamic assembly of cells into tissues. Recently, stem-cell biology has emerged as a bridge between the traditional fields of cell biology and developmental genetics. In addition to their potential therapeutic role, stem cells are being exploited as experimental ‘logic chips’ that integrate information and exhibit self-organizing properties. Recent studies provide new insights on how morphogenic signals coordinate major stem cell decisions to regulate the size, shape and cellular diversity of the nervous system.