Marked differences in differentiation propensity among human embryonic stem cell lines
Marked differences in differentiation propensity among human embryonic stem cell lines
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DOI：
10.1038/nbt1383
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发表时间：
2008-03-01
影响因子：
46.9
通讯作者：
Melton, Douglas A.
中科院分区：
文献类型：
--
作者：
Osafune, Kenji;Caron, Leslie;Melton, Douglas A.
比较了17个人胚胎干细胞系的分化潜能。一些品系表现出分化成特定谱系的显著倾向，通常在谱系特异性基因表达中具有> 100倍的差异。例如，HUES 8最适合胰腺分化，HUES 3最适合心肌细胞生成。hES细胞系之间发育潜力的这些重要差异表明筛选和衍生谱系特异性分化的细胞系的重要性。
The differentiation potential of 17 human embryonic stem (hES) cell lines was compared. Some lines exhibit a marked propensity to differentiate into specific lineages, often with > 100-fold differences in lineage-specific gene expression. For example, HUES 8 is best for pancreatic differentiation and HUES 3 for cardiomyocyte generation. These non-trivial differences in developmental potential among hES cell lines point to the importance of screening and deriving lines for lineage-specific differentiation.