Post-transcriptional regulation in attaching and effacing pathogens: integration of environmental cues and the impact on gene expression and host interactions.
Post-transcriptional regulation in attaching and effacing pathogens: integration of environmental cues and the impact on gene expression and host interactions.
复制标题
附着和消除病原体的转录后调控：环境线索的整合以及对基因表达和宿主相互作用的影响。
DOI：
10.1016/j.mib.2021.08.003
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发表时间：
2021
影响因子：
5.4
通讯作者：
Kendall,MelissaM
中科院分区：
文献类型：
--
作者：
Smallets,Sarah;Kendall,MelissaM
亮点细菌病原体感知宿主环境中的线索来协调基因表达并建立感染。转录后和翻译基因调控整合宿主信号以增强病原体对宿主的适应。附着和消失病原体依靠基于小RNA的蛋白质活性调控和控制来增强毒力。为了建立感染，肠道病原体整合环境线索来导航胃肠道并精确控制毒力决定子的表达。新数据表明，转录后和翻译后基因调控在毒力调控和病原体对宿主环境的适应中发挥着关键作用。在这里，我们重点介绍最近的研究，这些研究揭示了生理相关信号如何启动转录后和翻译后调节回路，以及对附着和消除病原体、肠致病性大肠杆菌、肠出血性大肠杆菌 O157:H7 和啮齿类柠檬酸杆菌中毒力基因表达的影响。
HighlightsBacterial pathogens sense cues in the host environment to coordinate gene expression and establish infection.Post-transcriptional and-translational gene regulation integrate host signals to enhance pathogen adaptation to the host.The attaching and effacing pathogens rely on small RNA-based regulation and control of protein activity to enhance virulence.To establish infection, enteric pathogens integrate environmental cues to navigate the gastrointestinal tract and precisely control expression of virulence determinants. Emerging data indicate that post-transcriptional and post-translational gene regulation plays a key role in virulence regulation and pathogen adaptation to the host environment. Here, we highlight recent studies that reveal how physiologically relevant signals initiate post-transcriptional and post-translational regulatory circuits and the impact on virulence gene expression in the attaching and effacing pathogens, enteropathogenic Escherichia coli, enterohemorrhagic E. coli O157: H7, and Citrobacter rodentium.