RATE OF RECOVERY OF VISION AFTER EARLY MONOCULAR DEPRIVATION IN KITTENS
RATE OF RECOVERY OF VISION AFTER EARLY MONOCULAR DEPRIVATION IN KITTENS
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DOI：
10.1113/jphysiol.1978.sp012164
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发表时间：
1978-01-01
影响因子：
5.5
通讯作者：
MITCHELL, DE
中科院分区：
文献类型：
--
作者：
GIFFIN, F;MITCHELL, DE
通过在不同年龄段的不同时间内将右眼眼睑合在一起，使15只小猫单眼失明。一个简单的行为技术被用来评估单眼剥夺的时间对视力的剥夺眼和任何随后的恢复的时间过程的直接影响。在通过反向缝合迫使动物使用其被剥夺的眼睛或在单眼闭塞的初始期后动物双眼睁开的条件下测量视力恢复的程度。单眼剥夺的初始影响的严重程度进行了分级，根据剥夺的年龄，范围从明显失明的动物剥夺在6周龄的小猫剥夺在12周龄的敏锐度只有一个小的损失。从出生起就被剥夺的影响特别严重，导致暂时失明。然而，经过一段时间后，随着剥夺的增加，所有动物在接下来的2个月或3个月的过程中显示出图案视觉的一些恢复。随着剥夺时间的延长，这种恢复的程度逐渐降低。在关键期至4个月期间完全剥夺的动物中，甚至有一些视力恢复（2.5周/度的敏锐度）。年龄。直接比较的行为恢复率之间的动物，反向缝合与同窝接受双眼输入后单眼闭塞45或60天的年龄证明是非常相似的，虽然最终达到的敏锐度，反向缝合的动物总是略高。在类似的情况下，观察到的回收率与观察到的视觉皮层细胞的眼优势的变化相当相关。虽然这些动物的恢复可以通过两只眼睛之间的竞争性相互作用的简单概念来解释，但在最初剥夺期后双眼睁开的动物中观察到的恢复并不容易解释。显然，必须有一个额外的非竞争性回收机制。
Fifteen kittens were monocularly deprived of vision by suturing the lids of the right eye together for various periods of time at different ages. A simple behavioral technique was used to assess the immediate effects of the period of monocular deprivation on the visual acuity of the deprived eye and the time course of any subsequent recovery. The extent of the recovery of vision was measured under conditions where the animal was either forced by reverse suture to use its deprived eye or where the animal had both eyes open after the initial period of monocular occlusion. The initial effects of monocular deprivation were graded in severity according to the age at which the deprivation was imposed, ranging from apparent blindness in animals deprived at 6 wk of age to only a small loss of acuity in kittens deprived at 12 wk of age. The effects of deprivation imposed from birth were particularly severe, leading to a temporary blindness. Nevertheless after a period of time that became progressively longer with increasing deprivation, all animals showed some recovery of pattern vision over the course of the next 2 or 3 mo. The extent of this recovery became progressively less as the period of deprivation was prolonged. There was even some recovery of vision (an acuity of 2.5 cycles/degree) in animals that were deprived thoroughout the duration of the critical period to 4 mo. of age. Direct comparison of the rate of behavioral recovery between animals that were reverse sutured with that of litter-mates that received binocular input after monocular occlusion to either 45 or 60 days of age proved to be remarkably similar, although the acuity that was eventually attained by the reverse sutured animals was always slightly higher. The recoveries observed after reverse suturing were reasonably well correlated with changes observed in the ocular dominance of visual cortical cells under similar circumstances. Although the recovery in these animals can be accounted for by the simple notion of a competitive interaction between the 2 eyes, the recovery observed in animals that had both eyes open after the initial period of deprivation cannot be so readily explained. Evidently there must be an additional non-competitive mechanism of recovery.