Androgjen receptor expression is inversely correlated with pathologic, tumor stage in bladder cancer
Androgjen receptor expression is inversely correlated with pathologic, tumor stage in bladder cancer
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DOI：
10.1016/j.urology.2004.03.025
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发表时间：
2004-08-01
期刊：
影响因子：
2.1
通讯作者：
Scherr, DS
中科院分区：
文献类型：
--
作者：
Boorjian, S;Ugras, S;Scherr, DS
目标。目的：探讨雄激素受体(AR)在膀胱移行细胞癌(TCC)中的表达及其与肿瘤病理分期的关系。男性膀胱移行细胞癌的发病率是女性的三倍。这种发病率性别差异的原因不明。我们评估了2002年7月至2003年6月期间在我们机构连续治疗的49例膀胱移行细胞癌患者的肿瘤标本。用小鼠抗AR单抗对经尿道电切、根治性膀胱切除或转移瘤切除的肿瘤石蜡包埋组织切片进行免疫组织化学染色。对标本进行AR表达评估，并在AR染色的肿瘤中记录染色阳性的细胞核的百分比。在49例肿瘤中，26例(53.1%)表达AR。随着病理分期的升高，表达AR的肿瘤由PTA病变的88.9%下降到PT3肿瘤的0%。总体而言，75%的浅表性肿瘤(Pta+Pt1+原位癌)表达AR，而浸润性肿瘤(Pt2+Pt3；P=0.002)表达AR。此外，在AR阳性表达的肿瘤中，PTA肿瘤中AR阳性细胞核的平均百分比(62.5%)显著高于PT1(31%)和PT2(20%)(P=0.005)。我们发现AR蛋白在肿瘤中的表达随着病理分期的升高而降低。我们的数据表明AR的表达缺失与浸润性膀胱癌有关。(C)2004年爱思唯尔公司。
Objectives. To evaluate the expression of the androgen receptor (AR) in transitional cell carcinoma (TCC) of the bladder, and to assess whether its expression correlated with pathologic tumor stage. TCC of the bladder is three times more common in males than in females. The origin of this sex difference in incidence is unknown.Methods. We evaluated tumor specimens from 49 consecutive patients treated for TCC of the bladder at our institution between July 2002 and June 2003. Immunohistochemistry was performed using a monoclonal mouse anti-AR antibody on paraffin-embedded tissue sections of tumors obtained from transurethral resection, radical cystectomy, or resection of metastases. Specimens were assessed for AR expression, and, in tumors that demonstrated AR staining, the percentage of nuclei that stained positive was recorded.Results. Of the 49 tumors, 26 (53.1%) expressed the AR. The percentage of tumors that expressed the AR decreased with increasing pathologic stage, from 88.9% of pTa lesions to 0% of pT3 tumors. Overall, 75% of superficial tumors (pTa + pT1 + carcinoma in situ) expressed the AR compared with 21.4% of invasive tumors (pT2 + pT3; P = 0.002). In addition, among AR-expressing tumors, the mean percentage of nuclei that stained positive for the AR was significantly greater in pTa tumors (62.5%) than in pT1 (31%) or pT2 (20%) tumors (P = 0.005).Conclusions. We found a decrease in AR protein expression in tumors with increased pathologic stage. Our data suggest that the loss of AR expression is associated with invasive bladder cancer. (C) 2004 Elsevier Inc.