Prediction of efficacy of antimicrobial agents in treatment of infections due to Chlamydia trachomatis.
Prediction of efficacy of antimicrobial agents in treatment of infections due to Chlamydia trachomatis.
复制标题
预测抗菌药物治疗沙眼衣原体感染的疗效。
DOI：
10.1093/infdis/138.5.655
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
E. Alexander
中科院分区：
文献类型：
--
作者：
W. Bowie;C. K. Lee;E. Alexander
虽然急性尿道炎患者的沙眼衣原体很容易通过全身治疗根除，但全身治疗对慢性沙眼的治疗效果不太满意。抗菌药物对C.当在C.沙眼衣原体的最小抑菌浓度（MIC）预测药物治疗尿道炎的功效，但不一定预测治疗慢性眼沙眼的功效。根除C.当在用C.沙眼衣原体的MIC超过几个μ m，米诺环素、强力霉素和利福平的活性明显高于四环素、红霉素或其他几种抗菌药物。在三种最有效的抗菌药物中，只有强力霉素已被全身用于治疗由念珠菌引起的眼部感染。沙眼，并且据报道它是已被利用的最有效的抗微生物剂。专性细胞内病原体如C.沙眼存在独特的问题。利用几种测试方法可能有助于确定具有改善临床疗效的抗菌药物，特别是在治疗眼沙眼方面。
Although Chlamydia trachomatis is readily eradicated by systemic therapy in patients with acute urethritis, systemic therapy is less satisfactory in treatment of chronic trachoma. The activities of antimicrobial agents against C. trachomatis in cell cultures when the antimicrobial agents are added 1 hr after the C. trachomatis (minimal inhibitory concentration [MIC]) predicts efficacy of the drugs in the treatment of urethritis but does not necessarily predict efficacy in the treatment of chronic ocular trachoma. Concentrations of antimicrobial agents required to eradicate C. trachomatis when the agents were added 48 hr after inoculation of the cell cultures with C. trachomatis exceeded the MIC by several logarithms, and minocycline, doxycycline, and rifampin were markedly more active than tetracycline, erythromycin, or several other antimicrobial agents. Of the three most active antimicrobial agents, only doxycycline has been used systemically to treat ocular infections due to C. trachomatis, and it has been reported to be the most effective antimicrobial agent that has been utilized. In vitro testing of obligate intracellular pathogens such as C. trachomatis presents unique problems. Utilization of several methods of testing may help to identify antimicrobial agents with improved clinical efficacy, particularly in the treatment of ocular trachoma.