Development and Application of alpha-Heteroatom Ketones in Asymmetric Michael Reaction with beta-trans-Nitroalkenes
Development and Application of alpha-Heteroatom Ketones in Asymmetric Michael Reaction with beta-trans-Nitroalkenes
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α-杂原子酮在与β-反式硝基烯烃的不对称迈克尔反应中的开发及应用
DOI：
10.1021/acs.joc.5b00013
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发表时间：
2015
影响因子：
3.6
通讯作者：
Wang Rui
中科院分区：
文献类型：
--
作者：
Yang Dongxu;Li Dan;Wang Linqing;Zhao Depeng;Wang Rui
报道了一种新型的N-苯基咪唑修饰的α杂原子酮的设计及其在β-反式硝基烯烃的不对称反选择Michael反应中的应用。得到了较高的产率和对映体选择性，相应的共轭加合物可以进一步转化为相应的手性酯和环丙烷衍生物，具有良好的对映选择性。
The successful design and application of a new type ofN-phenyl-imidazole-modified α-heteroatom ketones in asymmetricanti-selective Michael reactions with β-trans-nitroalkenes is reported. High yields and enantioselectivities could be obtained, and the corresponding conjugate adducts could be further transformed into related chiral esters and cyclopropane derivatives with excellent enantioselectivities.