ENHANCED NK CELL ACTIVITY IN MICE INJECTED WITH INTERFERON AND INTERFERON INDUCERS
ENHANCED NK CELL ACTIVITY IN MICE INJECTED WITH INTERFERON AND INTERFERON INDUCERS
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DOI：
10.1038/273759a0
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发表时间：
1978-01-01
期刊：
影响因子：
64.8
通讯作者：
GRESSER, I
中科院分区：
文献类型：
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作者：
GIDLUND, M;ORN, A;GRESSER, I
自然杀伤(NK)细胞是免疫系统中一个独特的细胞亚群1，2。它们存在于包括人类在内的几个物种的淋巴器官中，并在短时间内对几种细胞类型进行细胞溶解，特别是肿瘤细胞1-5。虽然NK细胞的活性水平受基因控制6，7，几种外界因素，包括细菌佐剂、动物病毒和NK敏感的肿瘤细胞，可以诱导活体NK细胞活性6-10的增加。这些药物中的几种也被认为可以增加小鼠对可移植肿瘤的抵抗力。这一作用可能是由NK细胞介导的，因为对同基因肿瘤的活体抵抗力与个体小鼠11、12的NK细胞活性水平呈正相关。病毒和几种免疫佐剂也是干扰素的诱导剂。在这里，我们提供了干扰素和干扰素诱导剂显著增强小鼠NK细胞活性的证据，并提示干扰素可能是许多不同药物在体内增强NK细胞活性的介体。
NATURAL KILLER (NK) cells constitute a distinct subgroup of cells within the immune system1,2. They are found in the lymphoid organs of several species including man and are cytolytic on contact in short-termin vitroassays for several cell types, in particular tumour cells1–5. Although the level of NK cell activity is under genetic control6,7, several extraneous agents, including bacterial adjuvants, animal viruses and NK-sensitive tumour cells induce an increase inin vivoNK cell activity6–10. Several of these agents are also known to increase the resistance of mice to transplantable tumours. This effect may be mediated by NK cells, as a positive correlation exists betweenin vivoresistance to syngeneic tumours and the levels of NK cell activity in the individual mice11,12. Viruses as well as several immunoadjuvants are also inducers of interferon. Here we present evidence that interferon and interferon inducers markedly enhance NK cell activity in mice, and suggest that interferon may be the mediator by which many different agents increase NK cell activityin vivo.