Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin
Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin
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血管解剖学定义了沿肠系膜边缘吲哚美辛诱发空肠溃疡的部位
DOI：
10.1136/gut.41.6.763
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发表时间：
1997
期刊：
影响因子：
24.5
通讯作者：
Andrew J. Wakefield
中科院分区：
文献类型：
--
作者：
A. Anthony;R. Pounder;Amar P. Dhillon;Andrew J. Wakefield
背景——吲哚美辛诱导大鼠空肠溃疡，但不影响回肠。溃疡位于沿着肠肠系膜边缘的直肠血管之间，这一观察结果尚未得到充分解释。目的——检查实验性溃疡的定位与大鼠小肠血管解剖结构之间的关系。方法——使用动脉碳墨水灌注研究和比较大鼠空肠和回肠的正常血管解剖结构。检查了吲哚美辛引起的早期和晚期病变的解剖定位，特别是脉管系统。 Mucosal injury induced by feeding vessel ligation for 24 hours or brief ischaemia-reperfusion injury was examined.在一项两剂量研究中测试了对吲哚美辛的解剖学敏感位点的存在。结果——在大鼠空肠中，肠系膜边缘血管化不良的部位非常容易受到吲哚美辛引起的损伤，而回肠中不存在这样的部位。绒毛收缩是大鼠空肠早期吲哚美辛损伤和缺血再灌注损伤的一个特征。空肠短血管二十四小时结扎选择性诱导肠系膜边缘缺血性损伤。给予大鼠两次剂量的吲哚美辛并没有比单次剂量引起更大的损伤。结论——结果支持这样的假设：大鼠空肠沿肠系膜边缘具有血管受损部位，容易受到吲哚美辛引起的损伤。吲哚美辛可能会选择性地在这些部位引起缺血再灌注损伤。
Background—Indomethacin induces ulceration in the rat jejunum with sparing of the ileum. The ulcers localise between vasa recta along the mesenteric margin of the bowel, observations that have not been fully explained. Aim—To examine the relationship between the localisation of experimental ulcers and the vascular anatomy of the rat small intestine. Methods—The normal vascular anatomy of the rat jejunum and ileum was studied and compared using arterial carbon ink perfusion. The anatomical localisation of early and advanced lesions induced by indomethacin was examined with particular reference to the vasculature. Mucosal injury induced by feeding vessel ligation for 24 hours or brief ischaemia-reperfusion injury was examined. The existence of anatomically sensitive sites to indomethacin was tested in a two dose study. Results—In the rat jejunum, poorly vascularised sites along the mesenteric margin were highly susceptible to indomethacin induced injury, such sites being absent from the ileum. Villous contraction was a feature of both early indomethacin injury and ischaemia-reperfusion injury in the rat jejunum. Twenty four hour ligation of jejunal vasa brevia selectively induced ischaemic injury along the mesenteric margin. Two doses of indomethacin to rats did not induce greater injury than a single dose. Conclusions—Results support the hypothesis that the rat jejunum possesses vascularly compromised sites along the mesenteric margin that are susceptible to indomethacin induced injury. Indomethacin may cause ischaemia-reperfusion injury selectively at these sites.
强烈的胃收缩导致粘膜缺血。
DOI：
10.1152/ajpgi.1991.260.3.g524
发表时间：
1991
期刊：
The American journal of physiology
影响因子：
--
作者：
Livingston,EH;Howard,TJ;Garrick,TR;PassaroJr,EP;Guth,PH
通讯作者：
Guth,PH