Rejuvenating Strategies of Tissue-specific Stem Cells for Healthy Aging
Rejuvenating Strategies of Tissue-specific Stem Cells for Healthy Aging
复制标题
组织特异性干细胞的健康老化策略
DOI：
10.14336/ad.2018.1119
复制
发表时间：
2019-08
影响因子：
7.4
通讯作者：
Hu Yi Ping
中科院分区：
文献类型：
--
作者：
Wang Min jun;Chen Jiajia;Chen Fei;Liu Qinggui;Sun Yu;Yan Chen;Yang Tao;Bao Yiwen;Hu Yi Ping
尽管衰老是一个生理过程，但由于全球人口快速老龄化带来的日益加重的负担，它引发了人们对衰老和 rejuvenation（回春、恢复活力，此处可能是“抗衰老”相关科学研究的特定表达，如“抗衰科学”）科学的兴趣。随着年龄的增长，内稳态维持和再生能力会下降。
Although aging is a physiological process, it has raised interest in the science of aging and rejuvenation because of the increasing burden on the rapidly aging global population. With advanced age, there is a decline in homeostatic maintenance and regenerative responsiveness to the injury of various tissues, thereby contributing to the incidence of age-related diseases. The primary cause of the functional declines that occur along with aging is considered to be the exhaustion of stem cell functions in their corresponding tissues. Age-related changes in the systemic environment, the niche, and stem cells contribute to this loss. Thus, the reversal of stem cell aging at the cellular level might lead to the rejuvenation of the animal at an organismic level and the prevention of aging, which would be critical for developing new therapies for age-related dysfunction and diseases. Here, we will explore the effects of aging on stem cells in different tissues. The focus of this discussion is on pro-youth interventions that target intrinsic stem cell properties, environmental niche component, systemic factors, and senescent cellular clearance, which are promising for developing strategies related to the reversal of aged stem cell function and optimizing tissue repair processes.
登录
查看更多内容
影响因子：
64.5
作者：
Scadden DT
通讯作者：
Scadden DT
影响因子：
16.6
作者：
Hosokawa K;MacArthur BD;Ikushima YM;Toyama H;Masuhiro Y;Hanazawa S;Suda T;Arai F
通讯作者：
Arai F
影响因子：
8.8
作者：
Brown K;Xie S;Qiu X;Mohrin M;Shin J;Liu Y;Zhang D;Scadden DT;Chen D
通讯作者：
Chen D
DOI：
10.18632/aging.101098
发表时间：
2016-11-14
期刊：
Aging
影响因子：
--
作者：
Oh J;Sinha I;Tan KY;Rosner B;Dreyfuss JM;Gjata O;Tran P;Shoelson SE;Wagers AJ
通讯作者：
Wagers AJ
影响因子：
20.1
作者：
Poggioli T;Vujic A;Yang P;Macias-Trevino C;Uygur A;Loffredo FS;Pancoast JR;Cho M;Goldstein J;Tandias RM;Gonzalez E;Walker RG;Thompson TB;Wagers AJ;Fong YW;Lee RT
通讯作者：
Lee RT