BETA2 MICROGLOBULIN AND LYMPHOCYTIC INFILTRATION IN SJOGRENS SYNDROME
BETA2 MICROGLOBULIN AND LYMPHOCYTIC INFILTRATION IN SJOGRENS SYNDROME
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DOI：
10.1056/nejm197512112932404
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发表时间：
1975-01-01
影响因子：
158.5
通讯作者：
GREY, HM
中科院分区：
文献类型：
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作者：
MICHALSKI, JP;DANIELS, TE;GREY, HM
我们测量了49名患者的唾液β 2微球蛋白浓度，这些患者通过唇唾液腺活检评估为干燥综合征。唾液浓度升高，并且浓度与活检中观察到的炎症程度之间存在显着相关性（P < 0.001）。135例干燥综合征患者的血清浓度升高。在伴有肾脏或淋巴组织增生性并发症的患者中观察到显著升高。3例患者血清β_2微球蛋白浓度随病情加重而升高，6例患者经有效治疗后血清β_2微球蛋白浓度下降，提示唾液β_2微球蛋白测定可为判断自身免疫性疾病局部炎症程度提供一种简便、无创的方法。（《新英格兰医学杂志》293：1228-1231，1975）
We measured salivary beta2microglobulin concentrations in 49 patients evaluated for Sjögren's syndrome with a labial salivary-gland biopsy. The salivary concentration was elevated and a significant correlation (P < 0.001) was found between the concentration and the degree of inflammation seen in the biopsy.Serum concentrations were increased in 135 patients with Sjögren's syndrome. Striking elevations were seen in patients with associated renal or lymphoproliferative complications. Three patients have an increase in serum beta2microglobulin concentration in association with exacerbation of their disease, and six a decrease after clinically efficacious therapy.These data indicate that determination of beta2microglobulin in saliva may provide a simple, noninvasive technic for estimation of the degree of local inflammation in autoimmune disease. (N Engl J Med 293:1228–1231, 1975)