sut-2 loss of function mutants protect against tau-driven shortened lifespan and hyperactive pharyngeal pumping in a C. elegans model of tau toxicity.
sut-2 loss of function mutants protect against tau-driven shortened lifespan and hyperactive pharyngeal pumping in a C. elegans model of tau toxicity.
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DOI：
10.17912/micropub.biology.000844
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发表时间：
2023
影响因子：
--
通讯作者：
Liachko, Nicole F
中科院分区：
文献类型：
--
作者：
Currey, Heather N;Kraemer, Brian C;Liachko, Nicole F
人tau蛋白在C. elegans神经元引起进行性的、与年龄相关的运动协调性丧失、选择性神经变性和寿命缩短。保守基因sut-2中的功能丧失（LOF）突变在tau蛋白病模型中保护免于进行性运动不协调和神经变性。为了确定sut-2 LOF是否也保护tau转基因C.在线虫中，我们进行了比较SUT-2的四种不同等位基因的寿命测定。 我们发现sut-2 LOF强烈抑制tau转基因动物的寿命缩短。我们还证明了tau转基因C.秀丽线虫表现出过度活跃的咽泵送，其通过SUT-2 LOF恢复。
Expression of human tau in C. elegans neurons causes progressive, age-associated loss of motor coordination, selective neurodegeneration, and shortened lifespan. Loss of function (LOF) mutations in the conserved gene sut-2 protects against progressive motor uncoordination and neurodegeneration in models of tauopathy. To determine whether sut-2 LOF also protects against shortened lifespan of tau transgenic C. elegans , we conducted lifespan assays comparing four different alleles of sut-2 . We found that sut-2 LOF robustly suppresses the shortened lifespan of tau transgenic animals. We also demonstrate that tau transgenic C. elegans exhibit hyperactive pharyngeal pumping, which is restored by sut-2 LOF.