Experimental gingivitis during pregnancy and post-partum: immunohistochemical aspects.
Experimental gingivitis during pregnancy and post-partum: immunohistochemical aspects.
复制标题
怀孕和产后实验性牙龈炎：免疫组织化学方面。
DOI：
10.1902/jop.1993.64.3.211
复制
发表时间：
1993
影响因子：
4.3
通讯作者：
L. Abraham
中科院分区：
文献类型：
--
作者：
J. Raber;W. Leene;C. Palmer;J. Raber;L. Abraham
研究了8例患者在妊娠和产后发生实验性牙龈炎的组织免疫学反应。在实验牙龈炎的第0天和第14天，怀孕期间的平均牙周袋出血指数（PPBI）高于产后，而斑块的积累量相似。妊娠期口腔上皮CD1阳性细胞（主要为朗格汉斯细胞）数量增多。然而，与产后相比，在妊娠期间，这些细胞的数量倾向于减少。妊娠期大鼠口腔和口腔上皮CD4阳性细胞数量明显增加（P < 0.05）。推测CD4阳性细胞数量的增加仅限于Th-1亚群，因为在怀孕期间发现CD14阳性细胞（主要是巨噬细胞和粒细胞）数量和B细胞数量减少。已知Th-1细胞对这些HLA II类抗原携带细胞具有细胞毒性。因此，针对B细胞和巨噬细胞的细胞毒性可能导致妊娠牙龈炎患者免疫反应性降低。
The histoimmunological response of 8 individuals was studied longitudinally in relation to the development of experimental gingivitis during pregnancy and post-partum. At day 0 as well as at day 14 of experimental gingivitis the mean periodontal pocket bleeding index (PPBI) was higher during pregnancy than post-partum, whereas the amount of plaque that accumulated was similar. The number of CD1 positive cells (mainly Langerhans) in the oral epithelium was found to be higher during pregnancy. In the sulcular epithelium, however, the number of these cells tended to decrease during pregnancy as compared to post-partum. The number of CD4 positive cells in oral and sulcular epithelium was increased during pregnancy (P < 0.05). It was speculated that this increase in the number of CD4 positive cells is confined to the Th-1 subset, since the number of CD14 positive cells (mainly macrophages and granulocytes) together with the number of B cells was found to be decreased during pregnancy. Th-1 cells are known to be cytotoxic against these HLA class II antigen bearing cells. Consequently, cytotoxicity directed against B cells and macrophages may result in diminished immunoresponsiveness in pregnancy gingivitis.