A "Brick Mass Spectrometer" Driven by a Sinusoidal Frequency Scanning Technique
A "Brick Mass Spectrometer" Driven by a Sinusoidal Frequency Scanning Technique
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由正弦频率扫描技术驱动的“砖式质谱仪”
DOI：
10.1021/acs.analchem.7b00719
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发表时间：
2017-05-16
影响因子：
7.4
通讯作者：
Xu, Wei
中科院分区：
文献类型：
--
作者：
Jiang, Ting;Zhang, Hongjia;Xu, Wei
在这项工作中，开发并表征了“砖”大小的微型质谱仪（28 cm X 21 cm X 16 cm），这是通过开发新的频率扫描技术实现的。与传统的电压扫描方法或数字离子阱上使用的数字波形不同，开发了一种正弦频率扫描技术来驱动砖式质谱仪（BMS）的线性离子阱。真空等离子体电离源和电喷雾电离源均与该 BMS 结合用于分析挥发性和非挥发性样品。探讨了 BMS 的稳定性图、灵敏度、质量分辨率和质量范围。这种新的频率扫描技术不仅可以减小微型质谱仪的尺寸和功耗，还可以提高其分析性能，特别是在质量范围和分辨率方面。类似于手机的发展，这种 BMS 将是从“砖块”质谱仪到“细胞”质谱仪的重要一步。
In this work, a "brick" size miniature mass spectrometer (28 cm X 21 cm X 16 cm) was developed and characterized, which was enabled by the development of a new frequency scanning technique. Different from the conventional voltage scanning method or the digital waveforms used on a digital ion trap, a sinusoidal frequency scanning technique was developed to drive the linear ion trap of the brick mass spectrometer (BMS). Both an in-vacuum plasma ionization source and an electrospray ionization source were coupled with this BMS for the analyses of volatile and nonvolatile samples. Stability diagram, sensitivity, mass resolution, and mass range of the BMS were explored. This new frequency scanning technique could not only reduce the size and power consumption of a miniature mass spectrometer but also improve its analytical performances, especially in terms of mass range and resolution. Analogous to the development of cell phones, this BMS would be an important step from "brick" mass spectrometer to "cell" mass spectrometer.