Resolution studies on two regioisomeric chiral stationary phases: Effects from reversed orientation of an amide group
Resolution studies on two regioisomeric chiral stationary phases: Effects from reversed orientation of an amide group
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DOI：
10.1016/j.chroma.2003.10.124
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发表时间：
2004-02-13
影响因子：
4.1
通讯作者：
Allenmark, S
中科院分区：
文献类型：
--
作者：
Thunberg, L;Allenmark, S
通过对一系列结构不同的外消旋化合物的色谱拆分，研究了两种新的聚合物手性固定相，它们分别含有选择剂trans-9，10-dihydro-9，10-ethanoanthracene-11，12-dicarboxylic酸双烯丙基酰胺1(DEABA)和反式-11，12-二氨基-9，10-二氢-9，10-乙基菲双丁烯基酰胺，2(DDEBB)。对于获得大分离因子的某些化合物组，通过使用不同的保留修饰剂进行了更详细的研究。由于两个选择剂中酰胺基团方向相反的影响，所研究的外消旋体在两个柱上以相反的洗脱顺序分离。(C)2003爱思唯尔B.V.保留所有权利。
Two new polymeric chiral stationary phases, incorporating the selectors trans-9,10-dihydro-9,10-ethanoanthracene-11,12-dicarboxylic acid bis-allylamide, 1 (DEABA) and trans-11, 12-diamino-9, 10-dihydro-9, 10-ethanoanthracene bis-butenoylamide, 2 (DDEBB), respectively, have been evaluated by chromatographic resolution of a series of structurally different racemates. For some groups of compounds, where large separation factors were obtained, more detailed studies were performed by the use of different retention modifiers. As an effect from the reversed orientation of the amide group in the two selectors, the enantiomers of the racemates investigated are separated in opposite order of elution on the two columns. (C) 2003 Elsevier B.V. All rights reserved.