Possible association of interleukin 1 gene locus polymorphisms with low back pain
Possible association of interleukin 1 gene locus polymorphisms with low back pain
复制标题
DOI：
10.1016/j.pain.2003.10.020
复制
发表时间：
2004-05-01
期刊：
影响因子：
7.4
通讯作者：
Riihimäki, H
中科院分区：
文献类型：
--
作者：
Solovieva, S;Leino-Arjas, P;Riihimäki, H
基于白细胞介素1（IL-1）活性与腰痛（LBP）相关的假设。我们研究了先前描述的功能性IL-1基因多态性与LBP之间的关系。受试者是芬兰研究队列的一个亚组。对131名中年男性进行了IL-1 α（C-889-T）、IL-1 β（C-3954-T）和IL-1受体拮抗剂（IL-1 RN）（G（1812）-A、G（1887）-C和T-11100-C）基因多态性检测。一份问卷调查了过去12个月内的个人和生活方式特征以及LBP的发生率、疼痛天数和因疼痛而限制日常活动的天数以及疼痛强度。腰椎间盘退变的确定与磁共振成像。IL-1 RNA（1812）等位基因携带者LBP的风险增加（OR 2.5，95%CI 1.0-6.0），该等位基因携带者与IL-1 α T（889）或IL-1 β T（3954）等位基因结合比非携带者具有更高的LBP风险和更多的LBP天数。疼痛强度与同时携带IL-1alphaT（889）和IL-1 RNA（1812）等位基因相关（OR 3.7。95% Cl 1.2-11.9）。考虑占位和椎间盘退变的多元回归分析显示，IL-IRNA（1812）等位基因的携带与疼痛的发生相关。疼痛天数和日常活动受限天数。携带IL-1 β T3954等位基因与疼痛天数相关。结果提示IL-1基因位点多态性可能参与LBP的发病机制。由于样本量较小，无法排除偶然发现的可能性。(C)2003年国际疼痛研究协会。出版社：Elsevier B. V. All rights reserved.
Based on a hypothesis that interleukin 1 (IL-1) activity is associated with low back pain (LBP). we investigated relationships between previously described functional IL-1 gene polymorphisms and LBP. The subjects were a subgroup of a Finnish study cohort. The IL-1alpha(C-889-T), IL-1beta(C-3954-T) and IL-1 receptor antagonist (IL-1RN)(G(1812)-A, G(1887)-C and T-11100-C) polymorphisms were genotyped in 131 middle-aged men from three occupational groups (machine drivers, carpenters and office workers). A questionnaire inquired about individual and lifestyle characteristics and the occurrence of LBP, the number of days with pain and days with limitation of daily activities because of pain, and pain intensity, during the past 12 months. Lumbar disc degeneration was determined with magnetic resonance imaging. Carriers of the IL-1RNA(1812) allele had an increased risk of LBP (OR 2.5, 95% Cl 1.0-6.0) and carriers of this allele in combination with the IL-1alphaT(889) or IL-1betaT(3954) allele had a higher risk of and more days with LBP than non-carriers. Pain intensity was associated with the simultaneous carriage of the IL-1alphaT(889) and IL-1RNA(1812) alleles (OR 3.7. 95% Cl 1.2-11.9). Multiple regression analyses allowing for occupation and disc degeneration showed that carriage of the IL-IRNA(1812) allele was associated with the occurrence of pain. the number of days with pain and days with limitations of daily activities. Carriage of the IL-1betaT3954 allele was associated with the number of days with pain. The results suggest a possible contribution of the IL-1 gene locus polymorphisms to the pathogenesis of LBP. The possibility of chance findings cannot be excluded due to the small sample size. (C) 2003 International Association for the Study of Pain. Published by Elsevier B.V.. All rights reserved.