AGE-RELATED DIFFERENCES IN VOLUMES OF SUBCORTICAL NUCLEI, BRAIN MATTER, AND CEREBROSPINAL-FLUID IN HEALTHY-MEN AS MEASURED WITH MAGNETIC-RESONANCE-IMAGING
AGE-RELATED DIFFERENCES IN VOLUMES OF SUBCORTICAL NUCLEI, BRAIN MATTER, AND CEREBROSPINAL-FLUID IN HEALTHY-MEN AS MEASURED WITH MAGNETIC-RESONANCE-IMAGING
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DOI：
10.1001/archneur.1992.00530320063013
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发表时间：
1992-08-01
影响因子：
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通讯作者：
HORWITZ, B
中科院分区：
文献类型：
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作者：
MURPHY, DGM;DECARLI, C;HORWITZ, B
磁共振成像用于确定27名健康男性的大脑，皮质下灰质核以及心室和肺脑脊髓液的体积。受试者分为年轻人（60岁，n = 17）组。将体积归一化为颅内体积百分比。与年轻男性相比，老年受试者的脑部质量明显少得多，脑脊液体积明显更大。在年龄较大的男性中，尾状核和凸状核的较小。当它们的体积表示为脑物质体积的比率时，这种显着差异仍然存在。这项横断面研究表明，健康受试者中与年龄相关的萎缩和脑脊液空间的同时扩张。在受影响的大脑区域中，尾状核和胸膜核的影响明显比大脑物物更大。这可能是衰老中的一些运动异常。
Magnetic resonance imaging was used to determine the volumes of brain, subcortical gray matter nuclei, and the ventricular and sulcal cerebrospinal fluid in 27 healthy men. Subjects were divided into young (60 years, n= 17) groups. Volumes were normalized as percent intracranial volume. Older subjects had significantly less brain mass and significantly larger ventricular and peripheral cerebrospinal fluid volumes than the younger men. The caudate and lenticular nuclei were significantly smaller in older than younger men. This significant difference remained when their volumes were expressed as a ratio of cerebral brain matter volume. This cross-sectional study demonstrates age-related atrophy and concurrent dilation of cerebrospinal fluid spaces in healthy subjects. Of brain regions affected, the caudate and lenticular nuclei are significantly more affected by healthy aging than is cerebral brain matter; this may account for some of the motor abnormalities in aging.