Ten thousand interactions for the molecular biologist
Ten thousand interactions for the molecular biologist
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DOI：
10.1038/nbt1018
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发表时间：
2004-10-01
影响因子：
46.9
通讯作者：
Russell, RB
中科院分区：
文献类型：
--
作者：
Aloy, P;Russell, RB
先前的研究表明，自然界只有大约1000个蛋白质折叠才能发挥各种各样的功能。在这里，我们使用来自不同来源和三维结构的蛋白质相互作用数据来表明相互作用类型的总数也是有限的，并估计自然界中的大多数相互作用将符合大约10,000种类型中的一种。我们目前知道的不到2000个，按照目前确定结构的速度，我们将需要20多年才能知道一个完整的代表性集合。
Previous studies have suggested that nature is restricted to about 1,000 protein folds to perform a great diversity of functions. Here, we use protein interaction data from different sources and three-dimensional structures to suggest that the total number of interaction types is also limited, and estimate that most interactions in nature will conform to one of about 10,000 types. We currently know fewer than 2,000, and at the present rate of structure determination, it will be more than 20 years before we know a full representative set.