Quantitative changes of lung tissue components during perinatal period in rats.
Quantitative changes of lung tissue components during perinatal period in rats.
复制标题
大鼠围产期肺组织成分的数量变化
DOI：
10.1292/jvms.61.1229
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
F. Sasaki
中科院分区：
文献类型：
--
作者：
Y. Morikawa;K. Fujii,;T. Okada;Y. Kiso;F. Sasaki
对胎龄18天至出生1天的大鼠肺组织成分(由PAS阳性和阴性上皮、血管和间质组成的气腔)的定量变化进行了观察。从胎龄18天到出生1天，左肺体积显著增大，20~21天气腔的百分率和体积显著增加。但是，从第20天到第21天，PAS阳性上皮排列的空间百分比显著减少，而PAS阴性上皮排列的空间百分比在这两天之间增加。增殖细胞核抗原(增殖细胞核抗原)阳性细胞在胎龄18天和19天的肺间质和肺上皮细胞中大量分布。胎龄18天至出生后1天，肺泡间质细胞百分率显著下降，20天至21天下降最为明显。胎龄20天以后，阳性细胞逐渐减少，定位于导气道上皮和间质。根据这些发现，本研究认为20~21天是胎肺发育的关键时期，20天前是肺的增殖期，21天后是肺功能分化的时期。
Quantitative changes of lung tissue components (air spaces lined by PAS-positive and PAS-negative epithelium, blood vessels and interstitium) were investigated in developing rats from fetal day 18 through neonatal day 1. The volume of the left lung increased significantly from fetal day 18 through neonatal day 1. The percentage and volume of the air spaces increased strikingly between fetal days 20 and 21. However, the percentage of the air spaces lined by PAS-positive epithelium decreased significantly from fetal days 20 to 21, and that of the spaces lined by PAS-negative epithelium increased between the two days. The proliferating cell nuclear antigen (PCNA)-positive cells were rich in the interstitium and epithelium of the air spaces on fetal days 18 and 19. The percentage of the interstitium decreased significantly from fetal day 18 through neonatal day 1, showing remarkable decrease between fetal days 20 and 21. From fetal day 20 onward, the PCNA-positive cells decreased in number and located in the epithelium of the conducting air ways and interstitium. Based upon these findings, the present study suggests that the period from fetal days 20 to 21 is a critical time for the development of fetal lung: the period before fetal day 20 is that for proliferation and the period after fetal day 21, functional differentiation of the lung.
大鼠粘液纤毛上皮的气管形态发生和胎儿发育。
DOI：
--
发表时间：
1984
期刊：
Scanning electron microscopy
影响因子：
--
作者：
McAteer,JA
通讯作者：
McAteer,JA