Differences and changes in human papillomavirus type 16 variant status in human immunodeficiency virus-positive adults are not uncommon.
Differences and changes in human papillomavirus type 16 variant status in human immunodeficiency virus-positive adults are not uncommon.
复制标题
人类免疫缺陷病毒阳性成人中人乳头瘤病毒 16 型变异状态的差异和变化并不罕见。
DOI：
10.1099/vir.0.018663-0
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
E. Unger
中科院分区：
文献类型：
--
作者：
M. Steinau;D. Swan;J. Onyekwuluje;J. Brooks;C. Vellozzi;E. Unger
Human papillomavirus type 16 (HPV-16) genotype variants have been the subject of several investigations, but study participants have rarely been sampled more than once. In this study, among a cohort of human immunodeficiency virus (HIV)-infected adults, HPV-16 variants were investigated in samples collected concurrently from the anus and cervix, as well as in serial samples collected from the same anatomical site at 12-month intervals. HPV-16 variants in stored extracts of cervical and anal samples were determined from subjects with multiple visits and at least one sample positive for HPV-16. Seven polymorphic nucleotide positions within the E6 region were analysed by pyrosequencing to determine genotype variants. Of 364 samples examined, 176 anal and 39 cervical swabs from 84 different subjects yielded unequivocal sequences of eight major HPV-16 variants. Eight samples contained probable novel HPV-16 variants and in one sample two variants were detected. In eight out of 29 (27.6%) anal-cervical sample pairs positive for HPV-16, discordant variants were found. From 57 anal and nine cervical sample series of HPV-16-positive samples, a change in HPV-16 variant status over time was seen in nine (13.6%) instances (seven anal and two cervical) from eight different participants. Changes in HPV-16 variants in HIV-infected adults were seen most frequently when different anatomical sites were sampled, but were also observed over time.
与人乳头瘤病毒 16 型变种相关的肛门原位癌风险。
DOI：
--
发表时间：
1998
期刊：
Cancer research.
影响因子：
--
作者：
Xi,LF;Critchlow,CW;Wheeler,CM;Koutsky,LA;Galloway,DA;Kuypers,J;Hughes,JP;Hawes,SE;Surawicz,C;Goldbaum,G;Holmes,KK;Kiviat,NB
通讯作者：
Kiviat,NB
脱落宫颈细胞的分子质量：对分子流行病学和生物标志物发现的影响。
DOI：
--
发表时间：
2004
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Habis,AngeliqueH;Vernon,SuzanneD;Lee,DaisyR;Verma,Mukesh;Unger,ElizabethR
通讯作者：
Unger,ElizabethR