Both CD1d antigen presentation and interleukin-12 are required to activate natural killer T cells during Trypanosoma cruzi infection
Both CD1d antigen presentation and interleukin-12 are required to activate natural killer T cells during Trypanosoma cruzi infection
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DOI：
10.1128/iai.73.3.1890-1894.2005
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发表时间：
2005-03-01
影响因子：
3.1
通讯作者：
Kahn, SJ
中科院分区：
文献类型：
--
作者：
Duthie, MS;Kahn, M;Kahn, SJ
自然杀伤T（NKT）细胞激活的机制仍不清楚。在这里，我们报告说，在锥虫克氏感染，白细胞介素-12（IL-12）缺乏或抗CD 1d抗体治疗，防止正常激活。所需的IL-12独立于MyD 88产生。这些数据支持需要IL-12和TCR刺激的正常NKT细胞活化模型。
Mechanisms of natural killer T (NKT)-cell activation remain unclear. Here, we report that during Trypanosoma cruzi infection, interleukin-12 (IL-12) deficiency or anti-CD1d antibody treatment prevents normal activation. The required IL-12 arises independently of MyD88. The data support a model of normal NKT-cell activation that requires IL-12 and TCR stimulation.