Increased lung cancer risk associated with the TERT rs2736100 polymorphism: an updated meta-analysis
Increased lung cancer risk associated with the TERT rs2736100 polymorphism: an updated meta-analysis
复制标题
DOI：
10.1007/s13277-014-1765-8
复制
发表时间：
2014-06-01
期刊：
影响因子：
--
通讯作者：
Jiao, Shunchang
中科院分区：
文献类型：
--
作者：
Yang, Jihua;Jiao, Shunchang
端粒酶逆转录酶（TERT）基因中的rs2736100多态性与多个人群的肺癌风险有关，但现有证据缺乏统计能力来得出令人信服的结论。因此，本研究旨在对 rs2736100 与肺癌风险之间的关联进行更精确的估计。对 PubMed、Embase 和 Web of Science 数据库进行了全面搜索，查找与 rs2736100 相关的肺癌风险的论文。使用固定或随机效应模型适当计算合并比值比 (OR) 和 95% 置信区间 (CI)。对涉及 39,715 例癌症病例和 61,462 名对照受试者的 20 项独立研究进行的荟萃分析显示，统计证据表明 rs2736100 与肺癌风险增加之间存在关联。按种族进行的亚组分析表明，亚洲人和白人人群之间存在显着关联。我们还发现非小细胞肺癌和肺腺癌的风险增加与 rs2736100 密切相关。这些数据提供了进一步的证据，支持 TERT rs2736100 的遗传易感性在肺癌发生中的作用。
The rs2736100 polymorphism in the telomerase reverse transcriptase (TERT) gene has been implicated in lung cancer risk in multiple populations, but the existing evidence lacks statistical power to draw a convincing conclusion. Therefore, the present study was devised to derive a more precise estimation of the association between rs2736100 and lung cancer risk. The PubMed, Embase, and Web of Science databases were comprehensively searched for papers concerning lung cancer risk in relation to rs2736100. Pooled odds ratios (ORs) and the 95 % confidence intervals (CIs) were appropriately calculated using the fixed or random effects model. Meta-analysis of 20 independent studies involving 39,715 cancer cases and 61,462 control subjects showed statistical evidence for an association between rs2736100 and increased risk of lung cancer. Subgroup analysis by ethnicity demonstrated a significant association among both Asian and Caucasian populations. We additionally found an increased risk of non-small cell lung cancer and lung adenocarcinoma strongly associated with rs2736100. These data provide further evidence supporting a role for genetic susceptibility of TERT rs2736100 in the development of lung cancer.