Immediate processing of erotic stimuli in paedophilia and controls: a case control study
Immediate processing of erotic stimuli in paedophilia and controls: a case control study
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DOI：
10.1186/1471-244x-13-88
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发表时间：
2013-03-19
期刊：
影响因子：
4.4
通讯作者：
Graf, Marc
中科院分区：
文献类型：
--
作者：
Habermeyer, Benedikt;Esposito, Fabrizio;Graf, Marc
背景：大多数调查恋童癖者性唤起的神经影像学研究都使用色情图片和阻塞的功能磁共振成像设计以及较长的刺激呈现时间。虽然这种方法可以检测到性唤起，但它不能评估对性显著刺激的即时处理。我们的研究目的是在异性恋男性恋童癖者和年龄匹配的健康对照中识别与色情刺激即时处理相关的神经网络。方法：我们在与事件相关的fmri设计中向8名恋童癖受试者和年龄匹配的对照组展示青春期前儿童和成人的色情图片。结果：女性色情图片激活了右侧颞叶、右侧顶叶和双枕叶，儿童色情图片激活了右侧背内侧前额叶皮层。右侧前外侧眶额叶皮层存在性别、年龄和群体的相互作用。结论：我们与事件相关的研究设计证实，当色情图片以块的形式呈现时，激活了一些已知与处理色情图片有关的大脑区域。此外，研究还发现，青春期前儿童的色情图片激活了两组人大脑中对选择反应策略至关重要的区域，而色情显著刺激选择性地激活了恋童癖受试者的一个大脑区域，这个区域之前被认为是与奖励和惩罚有关，并被证明与抑制色情反应和欺骗有关。
Background: Most neuroimaging studies investigating sexual arousal in paedophilia used erotic pictures together with a blocked fMRI design and long stimulus presentation time. While this approach allows the detection of sexual arousal, it does not enable the assessment of the immediate processing of erotically salient stimuli. Our study aimed to identify neuronal networks related to the immediate processing of erotic stimuli in heterosexual male paedophiles and healthy age-matched controls.Methods: We presented erotic pictures of prepubescent children and adults in an event related fMRI-design to eight paedophilic subjects and age-matched controls.Results: Erotic pictures of females elicited more activation in the right temporal lobe, the right parietal lobe and both occipital lobes and erotic pictures of children activated the right dorsomedial prefrontal cortex in both groups. An interaction of sex, age and group was present in the right anteriolateral oribitofrontal cortex.Conclusions: Our event related study design confirmed that erotic pictures activate some of the brain regions already known to be involved in the processing of erotic pictures when these are presented in blocks. In addition, it revealed that erotic pictures of prepubescent children activate brain regions critical for choosing response strategies in both groups, and that erotically salient stimuli selectively activate a brain region in paedophilic subjects that had previously been attributed to reward and punishment, and that had been shown to be implicated in the suppression of erotic response and deception.