Metabolic Coordination of Cell Fate by α-Ketoglutarate-Dependent Dioxygenases.
Metabolic Coordination of Cell Fate by α-Ketoglutarate-Dependent Dioxygenases.
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DOI：
10.1016/j.tcb.2020.09.010
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发表时间：
2021-01
影响因子：
19
通讯作者：
Finley LWS
中科院分区：
文献类型：
--
作者：
Baksh SC;Finley LWS
细胞命运的决定需要忠实地执行基因表达程序，这些程序越来越被认为是对新陈代谢输入的反应。特别是，依赖于α-酮戊二酸(αKG)的双加氧酶家族，包括几种染色质修饰酶，正在成为代谢控制细胞命运的关键介质。依赖αKG的双加氧酶消耗代谢物αKG(也称为2-氧代戊二酸)作为专性共底物，并被琥珀酸、富马酸和2-羟基戊二酸抑制。在这里，我们回顾了这些代谢物在控制双加氧酶活性和细胞命运程序中的作用。我们讨论了使这些代谢物能够控制细胞命运的生化和转录机制，并回顾了营养可获得性通过αKG依赖的双加氧酶影响组织特定命运计划的证据。
Cell fate determination requires faithful execution of gene expression programs, which are increasingly recognized to respond to metabolic inputs. In particular, the family of α-ketoglutarate (αKG)-dependent dioxygenases, which include several chromatin-modifying enzymes, are emerging as key mediators of metabolic control of cell fate. αKG-dependent dioxygenases consume the metabolite αKG (also known as 2-oxoglutarate) as an obligate cosubstrate and are inhibited by succinate, fumarate, and 2-hydroxyglutarate. Here, we review the role of these metabolites in the control of dioxygenase activity and cell fate programs. We discuss the biochemical and transcriptional mechanisms enabling these metabolites to control cell fate and review evidence that nutrient availability shapes tissue-specific fate programs via αKG-dependent dioxygenases.
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影响因子：
10.5
作者：
Chen C;Liu Y;Lu C;Cross JR;Morris JP 4th;Shroff AS;Ward PS;Bradner JE;Thompson C;Lowe SW
通讯作者：
Lowe SW
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1084/jem.20161087
发表时间：
2017-03-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Guitart AV;Panagopoulou TI;Villacreces A;Vukovic M;Sepulveda C;Allen L;Carter RN;van de Lagemaat LN;Morgan M;Giles P;Sas Z;Gonzalez MV;Lawson H;Paris J;Edwards-Hicks J;Schaak K;Subramani C;Gezer D;Armesilla-Diaz A;Wills J;Easterbrook A;Coman D;So CW;O'Carroll D;Vernimmen D;Rodrigues NP;Pollard PJ;Morton NM;Finch A;Kranc KR
通讯作者：
Kranc KR
影响因子：
50.3
作者：
Figueroa ME;Abdel-Wahab O;Lu C;Ward PS;Patel J;Shih A;Li Y;Bhagwat N;Vasanthakumar A;Fernandez HF;Tallman MS;Sun Z;Wolniak K;Peeters JK;Liu W;Choe SE;Fantin VR;Paietta E;Löwenberg B;Licht JD;Godley LA;Delwel R;Valk PJ;Thompson CB;Levine RL;Melnick A
通讯作者：
Melnick A
影响因子：
56.9
作者：
Chakraborty, Abhishek A.;Laukka, Tuomas;Kaelin, William G., Jr.
通讯作者：
Kaelin, William G., Jr.