Characteristics of animal models for COVID-19.
Characteristics of animal models for COVID-19.
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DOI：
10.1002/ame2.12278
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发表时间：
2022-10
影响因子：
3.7
通讯作者：
Qin, Chuan
中科院分区：
文献类型：
--
作者：
Qi, Feifei;Qin, Chuan
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)是2019年冠状病毒病(新冠肺炎)的病原体，是本世纪最严重的大流行，威胁人类健康和公共安全。SARS-CoV-2通过其基因组的突变而不断进化，出现了令人担忧的变种。世界卫生组织研发蓝图计划召集了一系列专家小组，为新冠肺炎开发动物模型，这是预防和控制SARS-CoV-2大流行的核心要求。在SARS-CoV和MERS-CoV大流行期间发展起来的动物模型构建技术被迅速部署并应用于新冠肺炎动物模型的建立。到目前为止，已经建立了大量的新冠肺炎动物模型，包括小鼠、仓鼠、水貂和非人灵长类动物。传染病根据病原体和感染方式的特点产生独特的表现。本文围绕SARS-CoV-2感染途径对动物模型资源进行了分类，总结了经鼻传播、局部传播和模拟传播途径构建的动物模型的特点。动物模型在发病机制和潜在的干预措施中起着至关重要的作用。本文就鼻腔感染、局部感染和模拟传播途径感染的动物模型的发展和特点作一综述。
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causative agent of coronavirus disease 2019 (COVID‐19), the most consequential pandemic of this century, threatening human health and public safety. SARS‐CoV‐2 has been continuously evolving through mutation of its genome and variants of concern have emerged. The World Health Organization R&D Blueprint plan convened a range of expert groups to develop animal models for COVID‐19, a core requirement for the prevention and control of SARS‐CoV‐2 pandemic. The animal model construction techniques developed during the SARS‐CoV and MERS‐CoV pandemics were rapidly deployed and applied in the establishment of COVID‐19 animal models. To date, a large number of animal models for COVID‐19, including mice, hamsters, minks and nonhuman primates, have been established. Infectious diseases produce unique manifestations according to the characteristics of the pathogen and modes of infection. Here we classified animal model resources around the infection route of SARS‐CoV‐2, and summarized the characteristics of the animal models constructed via transnasal, localized, and simulated transmission routes of infection. Animal models play crucial roles in the pathogenic mechanisms and potential interventions. In the current review, we summarized the development and characteristics of the animal models around transnasal infection, localized infection and simulated‐transmission route infection.
影响因子：
3.4
作者：
Jiang X;Li H;Liu Y;Bao L;Zhan L;Gao H;Deng W;Xue J;Liu J;Liu X;Li J;Wang J;Wu S;Yan M;Luo W;Jose PA;Qin C;Yang X;Zhang D;Yang Z
通讯作者：
Yang Z