The natural history and clinical characteristics of aspirin-exacerbated respiratory disease
The natural history and clinical characteristics of aspirin-exacerbated respiratory disease
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DOI：
10.1016/s1081-1206(10)62084-4
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发表时间：
2002-11-01
影响因子：
5.9
通讯作者：
Stevenson, DD
中科院分区：
文献类型：
--
作者：
Berges-Gimeno, MP;Simon, RA;Stevenson, DD
背景资料：阿司匹林加重的呼吸道疾病（AERD）是一种以慢性鼻炎、鼻息肉、哮喘以及摄入阿司匹林（阿萨）和大多数非甾体抗炎药（NSAID）后哮喘和鼻炎发作的沉淀为特征的临床综合征。在美国，关于这种疾病的大多数信息都来自邮寄样本或病人。目的：本研究的目的是检查300 AERD患者的自然史和临床特征，提到我们的机构阿司匹林desensitization.Methods：所有潜在的AERD患者进行了评估，使用一个标准的问卷调查，其中包括信息的临床特征和自然进展的疾病，以前的历史反应阿萨和其他非甾体抗炎药，目前使用的药物，种族背景。所有患者接受口服阿萨挑战，以证明他们有AERD。结果：从患者的历史，我们发现，平均年龄在发病的AERD是34岁，57%是女性。将阿萨计为NSAID，33%的患者之前对NSAID有两次反应，36%的患者对NSAID有三次以上反应，而在来我们进行评估之前，只有27%的患者对一种NSAID有反应。我们的患者平均每年有5.5次鼻窦炎发作。性别之间在临床特征或药物使用方面没有显著差异。种族是异质性的，在大多数participator.Conclusions：AERD开始在第三个十年的生活和两性。在历史发病和当前评价之间的13年内，疾病进展，随着时间的推移，鼻窦炎更多，需要控制药物，AERD没有种族或家族分布。
Background: Aspirin-exacerbated respiratory disease (AERD) is a clinical syndrome characterized by chronic rhinitis, nasal polyps, asthma, and precipitation of asthma and rhinitis attacks after ingestion of aspirin (ASA) and most nonsteroidal anti-inflammatory drugs (NSAIDs). Most information about the disease in the United States has come from,;mail samples or patients. Objective: The purpose of this study was to examine the natural history and clinical characteristics of 300 AERD patients, referred to our institution for aspirin desensitization.Methods: All potential AERD patients were evaluated using a standard questionnaire that included information about clinical characteristics and natural progression of their disease, previous history of reactions to ASA and other NSAIDs, current use of medications, and ethnic backgrounds. All patients underwent oral ASA challenges to prove they had AERD.Results: From patients' history we found that the average age at onset of AERD was 34 years, and that 57% were female. Counting ASA as an NSAID, 33% had previously reacted on two occasions to NSAIDs and 36% on more than three occasions to NSAIDs, whereas only 27% had reacted to one NSAID before they came to us for evaluation, Our patients had averaged 5.5 episodes of sinusitis per year. There were no significant differences in the clinical characteristics or use of medications between genders. Ethnicity was heterogeneous in most participants.Conclusions: AERD begins in the third decade of life and in both sexes. The disease progressed over the 13 years between historical onset and current evaluation, with more sinusitis and need for controller medications over time, There was no ethnic or familial distribution of AERD.