Chemoselective hydrogenation of imides catalyzed by Cp*Ru(PN) complexes and its application to the asymmetric synthesis of paroxetine
Chemoselective hydrogenation of imides catalyzed by Cp*Ru(PN) complexes and its application to the asymmetric synthesis of paroxetine
复制标题
DOI：
10.1021/ja067777y
复制
发表时间：
2007-01-17
影响因子：
15
通讯作者：
Ikariya, Takao
中科院分区：
文献类型：
--
作者：
Ito, Masato;Sakaguchi, Ayaka;Ikariya, Takao
这项工作代表了第一次催化亚胺加氢成酰胺和伯醇，其中独特的化学选择性源于催化剂中钌- nh部分的双功能性质。
This work represents the first catalytic hydrogenation of imides into amides and primary alcohols, in which the unique chemoselectivity is originated from the bifunctional nature of ruthenium-NH moiety in the catalyst.