Effects of digoxin and enalapril on heart period variability and response to head-up tilt in normal subjects.
Effects of digoxin and enalapril on heart period variability and response to head-up tilt in normal subjects.
复制标题
地高辛和依那普利对正常受试者心率变异性和抬头倾斜反应的影响。
DOI：
10.1016/0002-9149(93)90226-3
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Fleiss,JL
中科院分区：
文献类型：
--
作者：
Kaufman,ES;Bosner,MS;BiggerJr,JT;Stein,PK;Kleiger,RE;Rolnitzky,LM;Steinman,RC;Fleiss,JL
为探讨洋地黄和血管紧张素转换酶抑制剂对心电图RR间期变异性的影响，20名正常人随机、双盲、交叉试验，分别服用地高辛0.25 mg、依那普利10 mg和安慰剂，每日2次。分析每次治疗第5天获得的连续24小时心电图记录，并计算心动周期变异性的几个时域和功率谱测量值。地高辛显著增加（高达51%）的迷走神经调制指数的心脏周期，而不改变平均RR间期。依那普利没有改变任何措施的心脏周期变异性，尽管适度的高血压效应。为了确定每种治疗对立位应激反应的影响，10名受试者还接受了15分钟的60 °头高位倾斜;计算了15分钟0 °和60 °倾斜时的功率谱。两种积极治疗均不影响对头高位倾斜的反应。
To test the effects of digitalis and angiotensinconverting enzyme inhibition on the RR interval variability in an electrocardiogram, 20 normal subjects were given digoxin 0.25 mg, enalapril 10 mg, and placebo twice daily in a randomized, doubleblind, crossover study. Continuous 24-hour electrocardiographic recordings obtained on day 5 of each treatment were analyzed and several time domain and power spectral measures of heart period variability were calculated. Digoxin markedly increased (up to 51%) indexes of vagal modulation of heart period without changing mean RR interval. Enalapril did not change any measure of heart period variability despite a modest hypertensive effect. To determine the effect of each treatment on the response to orthostatic stress, 10 subjects also underwent 15 minutes of 60 ° headup tilt; power spectra were calculated for 15 minutes at 0 ° and at 60 ° of tilt. Neither active treatment affected the response to head-up tilt.