Circulating antibody against tumor necrosis factor-alpha protects rat brain from reperfusion injury
Circulating antibody against tumor necrosis factor-alpha protects rat brain from reperfusion injury
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DOI：
10.1097/00004647-199801000-00005
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发表时间：
1998-01-01
影响因子：
6.3
通讯作者：
Zlokovic, BV
中科院分区：
文献类型：
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作者：
Lavine, SD;Hofman, FM;Zlokovic, BV
肿瘤坏死因子-α（TNF-α）在脑损伤中的作用是有争议的。我们研究了抗TNF-α抗体在可逆性大脑中动脉闭塞大鼠模型中的作用。在局灶性缺血和早期再灌注。TNF-α迅速和短暂地释放到循环中。静脉注射抗TNF-α抗体预处理可减少皮质（71%，P < 0.015）和皮质下（58%，P < 0.007）损伤，增加再灌注期间的脑血流量，改善神经功能结局。这进一步支持了TNF-α是中风中的有害细胞因子的论点，而针对TNF-α的循环抗体可以保护脑免受再灌注损伤。
The role of tumor necrosis factor-alpha (TNF-alpha) in brain injury is controversial. We studied the effect of anti-TNF-alpha antibody in a rat model of reversible middle cerebral artery occlusion. During focal ischemia and early reperfusion. TNF-alpha was rapidly and transiently released into circulation. Pretreatment with intravenous anti-TNF-alpha antibody reduced cortical (71%, P < 0.015) and subcortical (58%, P < 0.007) injury, enhanced the cerebral blood flow during reperfusion, and improved the neurologic outcome. This further supports the contention that TNF-alpha is a deleterious cytokine in stroke, whereas circulating antibody against TNF-alpha may protect brain from reperfusion injury.