Cardiorenal Syndrome Pathophysiology
Cardiorenal Syndrome Pathophysiology
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DOI：
10.1016/j.ccl.2019.04.001
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发表时间：
2019-08-01
影响因子：
2.4
通讯作者：
Garimella, Pranav S.
中科院分区：
文献类型：
--
作者：
Kumar, Ujjala;Wettersten, Nicholas;Garimella, Pranav S.
肾综合征通常是指心脏和肾脏的集体功能障碍，导致级联反馈机制，导致两个器官的损害，并与不良临床结局相关。心肾综合征的病理生理学是复杂的、多因素的和动态的。提高对疾病机制的理解将有助于开发针对性的药物和非药物治疗方法来治疗这种综合征。本文讨论了心肾综合征的病理生理学的各种机制。
Cardiorenal syndrome commonly refers to the collective dysfunction of heart and kidney resulting in a cascade of feedback mechanism causing damage to both the organs and is associated with adverse clinical outcomes. The pathophysiology of cardiorenal syndrome is complex, multifactorial, and dynamic. Improving the understanding of disease mechanisms will aid in developing targeted pharmacologic and nonpharmacologic therapies for the management of this syndrome. This article discusses the various mechanisms involved in the pathophysiology of the cardiorenal syndrome.