Hemin particles-functionalized 3D printed scaffolds for combined photothermal and chemotherapy of osteosarcoma
Hemin particles-functionalized 3D printed scaffolds for combined photothermal and chemotherapy of osteosarcoma
复制标题
血红素颗粒功能化 3D 打印支架用于骨肉瘤光热联合化疗
DOI：
10.1016/j.cej.2021.129919
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发表时间：
2021-04-30
影响因子：
15.1
通讯作者：
Tao, Yu
中科院分区：
文献类型：
--
作者：
Dang, Wentao;Jin, Yuanyuan;Tao, Yu
在临床骨肿瘤治疗中，同时消除肿瘤细胞并填补肿瘤切除后的骨缺损，仍然极具挑战性。三维（3D）打印技术能够提供具有患者特异性精确几何形状和理想特性的支架，作为骨肿瘤治疗的一种有前景的选择，受到了广泛关注。在本研究中，我们通过在3D打印生物活性玻璃陶瓷（BGC - HMDOX）的支撑结构表面包覆氯化血红素和阿霉素（DOX），构建了多功能支架。由于表面的氯化血红素颗粒，BGC - HM - DOX支架在近红外激光照射下表现出优异的光热响应。此外，BGC - HM - DOX支架能够通过光热疗法与化疗相结合，在体外有效杀死骨肉瘤细胞，并在体内抑制肿瘤生长。因此，这种支架在肿瘤所致骨缺损的精准医疗方面可能具有很高的临床应用潜力。
Simultaneously eliminating tumor cells and filling the bone defects after tumor resection is still highly challenging for clinical bone tumor treatment. Three-dimensional (3D) printing technology, which provides scaffolds with patient-specific accurate geometry and desirable feature, has gained great attention for supplying a promising candidate for therapy of bone tumors. In this work, we constructed multifunctional scaffolds by coating hemin and doxorubicin (DOX) on the strut surface of 3D-printed bioactive glass ceramics (BGC-HMDOX). Owing to the surficial hemin particles, BGC-HM-DOX scaffolds showed excellent photothermal response under near-infrared laser irradiation. Besides, BGC-HM-DOX scaffolds could effectively kill osteosarcoma cells in vitro and suppress tumor growth in vivo via the combination of photothermal therapy and chemotherapy. Therefore, this scaffold may provide a high clinical potential for precision medicine in tumor-induced bone defect management.