AN OUTBREAK OF DIARRHEA AND HEMOLYTIC UREMIC SYNDROME FROM ESCHERICHIA-COLI O157-H7 IN FRESH-PRESSED APPLE CIDER
AN OUTBREAK OF DIARRHEA AND HEMOLYTIC UREMIC SYNDROME FROM ESCHERICHIA-COLI O157-H7 IN FRESH-PRESSED APPLE CIDER
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DOI：
10.1001/jama.269.17.2217
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发表时间：
1993-05-05
影响因子：
120.7
通讯作者：
GRIFFIN, PM
中科院分区：
文献类型：
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作者：
BESSER, RE;LETT, SM;GRIFFIN, PM
目的：大肠杆菌 O157:H7 引起出血性结肠炎和溶血性尿毒症综合征。 1991 年秋天，马萨诸塞州东南部爆发了大肠杆菌 O157:H7 感染，为识别看似不可能的媒介传播提供了机会。设计-病例对照研究以确定感染媒介。对新英格兰苹果酒生产商进行了调查，以评估生产实践，并确定苹果酒中大肠杆菌 O157:H7 微生物的存活时间。结果：疾病与饮用一种品牌的苹果酒显着相关。 18 名患者中有 13 名 (72%) 报告在疾病开始前一周饮用了苹果酒，但 49 名对照中只有 16 名 (33%) 报告饮用了苹果酒（比值比 [OR]，8.3；95% 置信区间 [CI]，1.8 至 39.7）。在喝苹果酒的患者中，13 名患者中的 12 名 (92%) 与 16 名对照者中的 2 名 (13%) 饮用来自苹果酒磨坊 A 的苹果酒（较低的 95% CI，2.9；P
Objective.-Escherichia coli O157:H7 causes hemorrhagic colitis and the hemolytic uremic syndrome. In the fall of 1991, an outbreak of E coli O157:H7 infections in southeastern Massachusetts provided an opportunity to identify transmission by a seemingly unlikely vehicle.Design.-Case-control study to determine the vehicle of infection. New England cider producers were surveyed to assess production practices and determined the survival time of E coli O157:H7 organisms in apple cider.Results.-Illness was significantly associated with drinking one brand of apple cider. Thirteen (72%) of 18 patients but only 16 (33%) of 49 controls reported drinking apple cider in the week before illness began (odds ratio [OR], 8.3; 95% confidence interval [CI], 1.8 to 39.7). Among those who drank cider, 12 (92%) of 13 patients compared with two (13%) of 16 controls drank cider from cider mill A (lower 95% CI, 2.9; P