ALTERATIONS IN PERMEABILITY OF ARTICULAR-CARTILAGE BY PROTEOLYTIC-ENZYMES
ALTERATIONS IN PERMEABILITY OF ARTICULAR-CARTILAGE BY PROTEOLYTIC-ENZYMES
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DOI：
10.1002/art.1780150312
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发表时间：
1972-01-01
影响因子：
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通讯作者：
GRANDA, JL
中科院分区：
文献类型：
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作者：
LOTKE, PA;GRANDA, JL
电解质和蛋白质渗透关节软骨的速率取决于它们的分子量和电荷。组织蛋白酶和胰蛋白酶能够增加渗透性，但单独的胶原酶不能。与单独用一种酶处理的软骨相比，用组织蛋白酶处理后再用胶原酶处理的软骨具有显著增加的渗透性。此外，可以假设酶诱导的软骨渗透性增加可能会改变基质内材料的流动，可能导致必需代谢物的浸出或改变其物理性质。这可能在软骨退化的发病机制中具有重要意义。
Electrolytes and proteins permeate articular cartilage at rates dependent on their molecular weight and charge. Cathepsin and trypsin are capable of increasing the permeability, but collagenase alone is not. Cartilage treated with cathepsin followed by treatment with collagenase has significantly increased permeability over cartilage treated by one enzyme alone. In addition, it may be postulated that enzyme‐induced increases in the permeability of cartilage may alter the flow of materials within the matrix, possibly leading to a leaching‐out of essential metabolites or altering its physical properties. This may be of significance in the pathogenesis of the degradation of cartilage.