Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
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DOI：
10.1056/nejmoa020177
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发表时间：
2003-01-16
影响因子：
158.5
通讯作者：
Coukos, G
中科院分区：
文献类型：
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作者：
Zhang, L;Conejo-Garcia, JR;Coukos, G
背景：虽然肿瘤浸润性T细胞已被记录在卵巢癌，一个明确的关联与临床outcome has not been established.Methods：我们进行了免疫组化分析186冷冻标本从晚期卵巢癌，以评估肿瘤浸润性T细胞的分布，并进行结果分析。在一些肿瘤中进行分子分析，通过实时聚合酶链反应。结果：CD3+肿瘤浸润性T细胞检测肿瘤细胞胰岛（肿瘤内T细胞）中的102 186个肿瘤（54.8%），他们在72个肿瘤（38.7%）检测不到，其余12个肿瘤（6.5%）无法评估。根据肿瘤内T细胞的存在与否，无进展生存期和总生存期的分布差异有统计学意义（P
Background:Although tumor-infiltrating T cells have been documented in ovarian carcinoma, a clear association with clinical outcome has not been established.Methods:We performed immunohistochemical analysis of 186 frozen specimens from advanced-stage ovarian carcinomas to assess the distribution of tumor-infiltrating T cells and conducted outcome analyses. Molecular analyses were performed in some tumors by real-time polymerase chain reaction.Results:CD3+ tumor-infiltrating T cells were detected within tumor-cell islets (intratumoral T cells) in 102 of the 186 tumors (54.8 percent); they were undetectable in 72 tumors (38.7 percent); the remaining 12 tumors (6.5 percent) could not be evaluated. There were significant differences in the distributions of progression-free survival and overall survival according to the presence or absence of intratumoral T cells (P