Ceramide kinase deficiency improves diet-induced obesity and insulin resistance
Ceramide kinase deficiency improves diet-induced obesity and insulin resistance
复制标题
DOI：
10.1016/j.febslet.2012.03.032
复制
发表时间：
2012-05-07
期刊：
影响因子：
3.5
通讯作者：
Igarashi, Yasuyuki
中科院分区：
文献类型：
--
作者：
Mitsutake, Susumu;Date, Tomomi;Igarashi, Yasuyuki
神经酰胺激酶（CERK）是一种磷酸化神经酰胺以产生1-磷酸神经酰胺的酶。最近，有证据表明CERK在免疫细胞的炎症信号传导中起作用。由于肥胖伴随着慢性、低度炎症，我们使用CERK缺失小鼠研究了CERK是否可能参与其中。我们确定CERK缺乏抑制饮食诱导的体重增加，并改善葡萄糖耐受不良。此外，我们证明了CERK缺乏减弱了浸润脂肪组织的巨噬细胞中的MCP-1/CCR 2信号传导，从而抑制了脂肪细胞中的炎症，否则可能导致肥胖和糖尿病。(C)2012年欧洲生物化学学会联合会。由Elsevier B出版。版权所有© 2016
Ceramide kinase (CERK) is an enzyme that phosphorylates ceramide to produce ceramide 1-phosphate. Recently, evidence has emerged that CERK has a role in inflammatory signaling of immune cells. Since obesity is accompanied by chronic, low-grade inflammation, we examined whether CERK might be involved using CERK-null mice. We determined that CERK deficiency suppresses diet-induced increases in body weight, and improves glucose intolerance. Furthermore, we demonstrated that CERK deficiency attenuates MCP-1/CCR2 signaling in macrophages infiltrating the adipose tissue, resulting in the suppression of inflammation in adipocytes, which might otherwise lead to obesity and diabetes. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.