The GSK-3/beta-catenin-signalling axis in smooth muscle and its relationship with remodelling.
The GSK-3/beta-catenin-signalling axis in smooth muscle and its relationship with remodelling.
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DOI：
10.1007/s00210-008-0269-8
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发表时间：
2008-08
影响因子：
3.6
通讯作者：
Schmidt, Martina
中科院分区：
文献类型：
--
作者：
Gosens, Reinoud;Meurs, Herman;Schmidt, Martina
β-连环蛋白是一种质膜相关蛋白，通过稳定钙粘蛋白介导的细胞-细胞接触和调节 TCF-/LEF 介导的基因转录，在细胞信号传导中发挥双重作用。传统上，β-连环蛋白在健康和疾病中的作用主要是在癌症等疾病的发育和不受控制的细胞生长的背景下研究的。然而，最近的研究结果表明，β-连环蛋白在多种器官系统的纤维增殖性疾病中也发挥着重要作用，并且β-连环蛋白调节平滑肌细胞的有丝分裂反应。由于多种内脏器官疾病的特征是平滑肌的结构和表型异常，包括纤维增殖反应增加，这些发现表明 β-连环蛋白可能发挥广泛的病理生理学作用。本文将回顾 β-连环蛋白和平滑肌中相关细胞内信号传导的潜在新作用，并讨论其在平滑肌重塑中发挥核心作用的假设。
β-Catenin is a plasma membrane-associated protein that plays a dual role in cellular signalling by stabilizing cadherin mediated cell–cell contact and by regulating TCF-/LEF-mediated gene transcription. Traditionally, the role of β-catenin in health and disease has mainly been studied in the context of development and uncontrolled cell growth in diseases such as cancer. Recent findings indicate, however, that β-catenin also plays a significant role in fibro-proliferative diseases of several organ systems and that β-catenin regulates mitogenic responses of smooth muscle cells. As several diseases of the internal organs are characterized by structural and phenotypic abnormalities of smooth muscle, including increased fibro-proliferative responses, these findings implicate that β-catenin could play a broad pathophysiological role. This article will review this potential novel role for β-catenin and associated intracellular signalling in smooth muscle and discuss the hypothesis that it plays a central role in smooth muscle remodelling.
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DOI：
10.1165/rcmb.2005-0277oc
发表时间：
2006-03-01
影响因子：
6.4
作者：
Douglas, IS;del Valle, FD;Voelkel, NF
通讯作者：
Voelkel, NF
影响因子：
5
作者：
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影响因子：
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作者：
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影响因子：
6
作者：
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通讯作者：
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影响因子：
5.3
作者：
George, S. J.;Beeching, C. A.
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